W1628

Wortmannin

From Penicillium funiculosum, ≥98% (HPLC), phosphatidylinositol 3-kinase inhibitor, powder

• Sinónimos: KY 12420
• Fórmula empírica (notación de Hill): C₂₃H₂₄O₈
• Número CAS: 19545-26-7
• Peso molecular: 428.43
• NACRES: NA.77
• PubChem Substance ID: 24278777
• UNSPSC Code: 12352207
• MDL number: MFCD00133927
• Beilstein/REAXYS Number: 67676
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: Wortmannin, from Penicillium funiculosum, ≥98% (HPLC)
• biological source: Penicillium funiculosum
• Quality Segment: 300
• assay: ≥98% (HPLC)
• form: powder
• color: off-white to yellow
• solubility: H₂O: unstable, acetonitrile: soluble
• storage temp.: 2-8°C
• SMILES string: [H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C3=C2C(=O)c4occ5C(=O)O[C@H](COC)[C@@]3(C)c45
• InChI: 1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
• InChI key: QDLHCMPXEPAAMD-QAIWCSMKSA-N
• Gene Information: human ... PIK3CD(5293), PIK3CG(5294), PIK3R1(5295)

Descripción

Biochem/physiol Actions

Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC₅₀ of 2-4 nM.

Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC₅₀ of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS06
• Palabra de advertencia: Danger
• Códigos de peligro: H300 + H310 + H330
• Indicaciones de precaución: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Acute Tox. 2 Dermal
• Clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges