T6829

TUG-424

≥98% (HPLC)

• Sinónimos: 3-(4-(o-Tolylethynyl)phenyl)propanoic acid
• Fórmula empírica (notación de Hill): C₁₈H₁₆O₂
• Número CAS: 1082058-99-8
• Peso molecular: 264.32
• NACRES: NA.77
• PubChem Substance ID: 329826854
• UNSPSC Code: 12352200
• MDL number: MFCD12912449
• Assay: ≥98% (HPLC)

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• solubility: DMSO: >10 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: Cc1ccccc1C#Cc2ccc(CCC(O)=O)cc2
• InChI: 1S/C18H16O2/c1-14-4-2-3-5-17(14)12-10-15-6-8-16(9-7-15)11-13-18(19)20/h2-9H,11,13H2,1H3,(H,19,20)
• InChI key: FODHWOBAQBTTFS-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

TUG-424 is expected to be useful in the exploration of FFA1 and may also be valuable as a lead structure for new potential antidiabetic therapeutics.

TUG-424 is expected to be useful in the exploration of FFA1 and may also be valuable as a lead structure for new potential antidiabetic therapeutics. TUG-424 significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity. It enhanced glucose-stimulated insulin secretion in a rat beta-cell line already at 100 nM and from isolated mouse islets through FFA1.

GPR40 (now FFA1) was formerly an orphan GPCR whose endogenous ligands have recently been identified as free fatty acids (FFAs). The receptor appears to be involved in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release.

Información de seguridad

• Pictogramas: GHS07,GHS09
• Palabra de advertencia: Warning
• Códigos de peligro: H319,H410
• Indicaciones de precaución: P264 - P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): dust mask type N95 (US), Eyeshields, Gloves