T1126

Thyroglobulin from porcine thyroid gland

powder

• Sinónimos: TG human
• Número CAS: 9010-34-8
• UNSPSC Code: 12352202
• EC Number: 232-721-3
• NACRES: NA.61
• MDL number: MFCD00132429
• Form: powder
• Biological source: Porcine thyroid
• Mol wt: ~670 kDa

Propiedades

• biological source: Porcine thyroid
• Quality Segment: 200
• form: powder
• mol wt: ~670 kDa
• composition: Iodine, ≥0.3%
• nitrogen analysis: 14.0-17.5% total
• technique(s): protein purification: suitable
• ash: ≤4%
• pI: 4.58
• UniProt accession no.: F1RRV3
• storage temp.: −20°C
• Gene Information: pig ... TG(100156471)

Descripción

Biochem/physiol Actions

Thyroglobulin has been shown to regulate the transcription of iodide porters including sodium iodide symporter and pendrin.

Thyroglobulin is a major protein involved with iodine metabolism. It consists of an iodine-containing protein that is stored in the thyroid gland and is converted into circulating thyroxines when the thyroid is stimulated by TSH (Thyroid Stimulating Hormone) from the pituitary. Thyroglobulin is often used as a carrier protein for the production of antibodies. Its advantage as a carrier protein comes from its large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Preparation Note

When reconstituted in water (20 mg/ml), a turbid solution with some insolubles is observed.

Other Notes

Electrophoretically heterogeneous.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): Eyeshields, Gloves, type N95 (US)