SML3634

TRULI

≥98% (HPLC), YAP signaling activator, powder

• Sinónimos: N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
• Fórmula empírica (notación de Hill): C₁₈H₁₄N₄OS
• Número CAS: 1424635-83-5
• Peso molecular: 334.39
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: TRULI, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(C1=CNC2=C1C=CC=N2)N=C3SC=CN3CC4=CC=CC=C4
• InChI: 1S/C18H14N4OS/c23-17(15-11-20-16-14(15)7-4-8-19-16)21-18-22(9-10-24-18)12-13-5-2-1-3-6-13/h1-11H,12H2,(H,19,20)
• InChI key: VTXBMVZVPUSAJF-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

Cell penetrant, potent and non-toxic activator of Yap signaling; inhibitor of Lats kinases

TRULI is a call penetrant, potent and non-toxic activator of Yap signaling. TRULI is an ATP-competitive inhibitor of Lats kinases (the core enzymes in Hippo signaling) that induces robust Yap nuclear translocation and prevents Yap phosphorylation. TRULI induces proliferation of supporting cells in the murine inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable