SML3575

TY-51469

≥98% (HPLC)

• Sinónimos: 2-[4-[[(5-Fluoro-3-methylbenzo[b]thien-2-yl)sulfonyl]amino]-3-(methylsulfonyl)phenyl]-4-thiazolecarboxylic acid, TY 51469
• Fórmula empírica (notación de Hill): C₂₀H₁₅FN₂O₆S₄
• Número CAS: 603987-59-3
• Peso molecular: 526.60
• UNSPSC Code: 12352200
• NACRES: NA.21
• MDL number: MFCD16628177
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: FC1=CC2=C(C=C1)SC(S(NC3=CC=C(C=C3S(C)(=O)=O)C4=NC(C(O)=O)=CS4)(=O)=O)=C2C
• InChI key: CBRCULCCRGSSLB-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

Potent and selective chymase inhibitor that prevents development and progression of non-alcoholic steatohepatitis in rats

TY-51469 is a potent and selective chymase inhibitor that prevents development and progression of non-alcoholic steatohepatitis in rats. TY-51469 inhibits activation of intestinal MMP-9 and prevents intestinal damage in indomethacin-induced small intestinal damage in rats. Also TY-51469 might protect against pancreatic islet disorganization.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable