SML3419

Koumine

≥95% (HPLC)

• Sinónimos: (3S,4S,4aR,6R,11bS,11cS)-11c-Ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-6,4, CID 91895267
• Fórmula empírica (notación de Hill): C₂₀H₂₂N₂O
• Número de CAS: 1358-76-5
• Peso molecular: 306.40
• MDL number: MFCD23103746
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: powder
• optical activity: [α]/D 295 to 245°
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: -10 to -25°C

Descripción

Biochem/physiol Actions

Koumine is a major indole alkaloid isolated from poisonous plant Gelsemium elegans that exhibits anti-inflammatory and analgesic effects in inflammatory and neuropathic pain models. It appears that koumine ameliorate chronic constriction injury induced neurotic pain through induction of autophagy and the inhibition apoptosis in the spinal cord of rodents. Koumine protects IPEC-J2 cells from hydrogen peroxide induced oxidative stress and apoptosis through decreasing reactive oxygen species (ROS) production.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H300 + H330
• pcodes: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3