SML2647

CA3

≥97% (HPLC)

• Sinónimos: 1,1′-[[9-(Hydroxyimino)-9H-fluorene-2,7-diyl]bis(sulfonyl)]bis-piperidine, 2,7-bis(1-Piperidinylsulfonyl)-9H-fluoren-9-one oxime, CIL56
• Fórmula empírica (notación de Hill): C₂₃H₂₇N₃O₅S₂
• Número CAS: 300802-28-2
• Peso molecular: 489.61
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00323348
• Assay: ≥97% (HPLC)
• Form: powder

Propiedades

• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [S](=O)(=O)(N5CCCCC5)c1cc2c(cc1)c3c(cc(cc3)[S](=O)(=O)N4CCCCC4)C2N=O
• InChI: 1S/C23H27N3O5S2/c27-24-23-21-15-17(32(28,29)25-11-3-1-4-12-25)7-9-19(21)20-10-8-18(16-22(20)23)33(30,31)26-13-5-2-6-14-26/h7-10,15-16,23H,1-6,11-14H2
• InChI key: YLRXSLQNJCJWGZ-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

CA3 is a potent and selective inhibitor of YAP1 (Hippo co-activator Yes-associated protein 1) that inhibits YAP1 expression and transcriptional activity in esophageal adenocarcinoma (EAC) cell lines. CA3 potently inhibits growth, induces apoptosis in radiation resistant CSC (cancer stem cell) enriched EAC cells. It inhibits tumor growth of in xenograft model with no apparent toxicity.

potent and selective inhibitor of YAP1 that inhibits YAP1 expression and transcriptional activity in EAC cell lines

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable