SML2181

SA4503

≥98% (HPLC)

• Sinónimos: 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride, AGY 94806, AGY94806, Cutamesine, SA 4503
• Fórmula empírica (notación de Hill): C₂₃H₃₂N₂O₂ · 2HCl
• Número CAS: 165377-44-6
• Peso molecular: 441.43
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD09842336
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: COC1=CC=C(CCN2CCN(CCCC3=CC=CC=C3)CC2)C=C1OC
• InChI: 1S/C23H32N2O2.2ClH/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20;;/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3;2*1H
• InChI key: XWOXAKBQEMQMFH-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

High affinity, orally active non-opioid intracellular receptor sigma-1 (σ1R) selective agonist with in vivo efficacy in experimental mice and rats.

SA4503 is a high affinity, orally active non-opioid intracellular receptor sigma-1 (σ1R) selective agonist (IC50 = 17.4 nM against 200 nM (+)-pentazocine for binding σ1R), exhibiting ~100-fold less affinity for the sigma 2 receptor subtype (σ2R) and little or no affinity toward 36 other receptors, ion channels and second messenger systems. Oral administration is reported to elicit cerebral acetylcholine (ACh) release in rat frontal cortex and hippocampus (5-20 mg/kg p.o.) and reduce immobility time in a mouse forced swimming test (Immobility time = 214.8 s without vs. 111.6 s with 1.0 mg/kg oral dosage).

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable