SML1886

VPC-13566

≥98% (HPLC)

• Sinónimos: 2-(7-Methyl-1H-indol-3-yl)quinoline
• Fórmula empírica (notación de Hill): C₁₈H₁₄N₂
• Número CAS: 218464-59-6
• Peso molecular: 258.32
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC1=CC=CC2=C1NC=C2C3=NC4=CC=CC=C4C=C3
• InChI key: FPKBNOVQNMJTEJ-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

VPC-13566 is Binding Function 3 (BF3)-specific inhibitor of the androgen receptor.

VPC-13566 is Binding Function 3 (BF3)-specific inhibitor of the androgen receptor. VPC-13566 potently inhibits AR transcriptional activity by displacement of the BAG1L peptide from the BF3 pocket. VPC-13566 inhibits the growth of various prostate cancer cell lines including an enzalutamide-resistant cell line and inhibits the growth of AR-dependent prostate cancer xenograft in mice.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable