SML1857

LRE1

≥98% (HPLC)

• Sinónimos: 6-Chloro-N4-cyclopropyl-N4-(2-thienylmethyl)-2,4-pyrimidinediamine, RU-0204277
• Fórmula empírica (notación de Hill): C₁₂H₁₃ClN₄S
• Número CAS: 1252362-53-0
• Peso molecular: 280.78
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD23148480
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: ClC1=CC(N(C2CC2)CC3=CC=CS3)=NC(N)=N1
• InChI key: PDWZXKSZLRVSEH-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

LRE1 is a selective allosteric inhibitor of soluble adenylyl cyclase (sAC), a ubiquitously expressed, essential component of cAMP-signaling. In contrast to G-protein-regulated transmembrane adenylyl cyclase, soluble adenylyl cyclase is directly activated by calcium and carbonate, and is dispersed throughout the cell cytoplasm. LRE1 was found to bind to the bicarbonate activator binding site. It inhibited cAMP accumulation in 4-4 cells with an IC50 of 11 μM, similar to that of KH7 and without its cellular toxicity.

Selective allosteric inhibitor of soluble adenylyl cyclase (sAC)

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3