SML1315

Ranirestat

≥97% (HPLC)

• Sinónimos: (3R)-2′-[(4-Bromo-2-fluorophenyl)methyl]-spiro[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-a]pyrazine]-1′,2,3′,5(2′H)-tetrone., AS-3201
• Fórmula empírica (notación de Hill): C₁₇H₁₁BrFN₃O₄
• Número CAS: 147254-64-6
• Peso molecular: 420.19
• NACRES: NA.77
• PubChem Substance ID: 329825780
• UNSPSC Code: 12352200
• MDL number: MFCD00920915
• Assay: ≥97% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• optical activity: [α]/D -5 to -10°, c = 1.0 in methanol
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=C(N1CC2=C(F)C=C(Br)C=C2)C3=CC=CN3[C@@]4(CC(NC4=O)=O)C1=O
• InChI: 1S/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1
• InChI key: QCVNMNYRNIMDKV-QGZVFWFLSA-N

Descripción

Biochem/physiol Actions

Ranirestat (AS-3201) is an aldose reductase (AR) inhibitor.

Ranirestat (AS-3201) is an aldose reductase (AR) inhibitor. Aldose reductase is a rate-limiting enzyme in the conversion of D-glucose to fructose via D-sorbitol. Ranirestat has been implicated in diabetic complications (cataract formation, retinopathy, neuropathy, nephropathy). Ranirestat prevents sorbitol accumulation and is thus hoped to be effective in the remedy of diabetic neuropathy.

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H315,H319,H335
• Indicaciones de precaución: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos diana: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable