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SML1073

Sigma-Aldrich

BIX

≥98% (HPLC)

Sinónimos:

2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid, BiP protein Inducer X

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About This Item

Fórmula empírica (notación de Hill):
C9H7NO3S
Número de CAS:
101714-41-4
Peso molecular:
209.22
Número MDL:
MFCD22415334
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329825455
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

powder

color

white to beige

solubilidad

DMSO: 20 mg/mL, clear

temp. de almacenamiento

2-8°C

cadena SMILES

OC1=C(O)C=C(C(CSC#N)=O)C=C1

InChI

1S/C9H7NO3S/c10-5-14-4-9(13)6-1-2-7(11)8(12)3-6/h1-3,11-12H,4H2

Clave InChI

SVFLBLCWKKQKDW-UHFFFAOYSA-N

Aplicación

BIX has been used in cell viability assay.

Acciones bioquímicas o fisiológicas

BIX (BiP protein inducer X) induces the expression of the endoplasmic reticulum chaperone protein GRP78 (glucose regulated protein 78, BiP) leading to an attenuation of the unfolded protein response. BIX protects neuronal cells and retinal cells from ER-stress induced cell death.
BIX is an inducer of molecular chaperone GRP78 (BIP, Glucose regulated protein 78).

Otras notas

air sensitive

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H317

Clasificaciones de peligro

Skin Sens. 1

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000435753
0000435751
0000435751
0000435753
0000423942

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Marta Kramer Mikkelsen et al.
BMC cancer, 18(1), 934-934 (2018-09-29)
Several intervention studies have demonstrated that exercise training has beneficial effects among cancer patients. However, older cancer patients are underrepresented in clinical trials, and only few exercise-based studies have focused specifically on older patients with cancer. In particular, research investigating the
X Xie et al.
Current molecular medicine, 18(1), 3-14 (2018-03-27)
Vascular network formation induced by angiogenesis plays an important role in many physiological and pathological processes. However, the role of blood flow and underlying mechanisms in vascular network formation, for example for the development of the caudal vein plexus (CVP)
Ling Xiao et al.
Circulation, 142(25), 2443-2455 (2020-10-24)
Ibrutinib is a Bruton tyrosine kinase inhibitor with remarkable efficacy against B-cell cancers. Ibrutinib also increases the risk of atrial fibrillation (AF), which remains poorly understood. We performed electrophysiology studies on mice treated with ibrutinib to assess inducibility of AF.
Myungjin Jo et al.
Genome research, 27(9), 1487-1500 (2017-06-10)
To understand disease mechanisms, a large-scale analysis of human-yeast genetic interactions was performed. Of 1305 human disease genes assayed, 20 genes exhibited strong toxicity in yeast. Human-yeast genetic interactions were identified by en masse transformation of the human disease genes
Dana M Hardbower et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(5), E751-E760 (2017-01-18)
Macrophage activation is a critical step in host responses during bacterial infections. Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine metabolism, has been well studied in epithelial cells and is known to have essential roles in many different cellular functions.
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