SML0632

Fialuridine

≥98% (HPLC), powder, nucleoside analog

• Sinónimos: 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-Pyrimidinedione, FIAU
• Fórmula empírica (notación de Hill): C₉H₁₀FIN₂O₅
• Número CAS: 69123-98-4
• Peso molecular: 372.09
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825571
• NACRES: NA.77
• MDL number: MFCD00866922
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: Fialuridine, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: −20°C
• SMILES string: F[C@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(NC(C(I)=C2)=O)=O
• InChI: 1S/C9H10FIN2O5/c10-5-6(15)4(2-14)18-8(5)13-1-3(11)7(16)12-9(13)17/h1,4-6,8,14-15H,2H2,(H,12,16,17)/t4-,5+,6-,8-/m1/s1
• InChI key: IPVFGAYTKQKGBM-BYPJNBLXSA-N

Descripción

General description

Fialuridine (1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)-5-iodouracil, or FIAU) is an antiviral agent. It is a thymidine-based nucleoside analogue.

Application

Fialuridine has been used in the selection of clones.

Biochem/physiol Actions

Fialuridine is a nucleoside analog antiviral agent.

Fialuridine is a nucleoside analog antiviral agent. The compound displays significant mitochondrial toxicity.

Fialuridine (1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)-5-iodouracil, or FIAU) and its metabolites blocks DNA polymerase at sites of multiple adjacent analog incorporation, reduces the presence of mtDNA (mitochondrial DNA) and results in mitochondrial structural defects in cultured hepatoblasts. It is considered as an efficient drug against hepatitis B virus (HBV) infection.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable