SML0539

T863

≥98% (HPLC), DGAT1 inhibitor, powder

• Sinónimos: 2-((1,4-trans)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)- phenyl)cyclohexyl)acetic acid, T-863, trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-cyclohexaneacetic acid
• Fórmula empírica (notación de Hill): C₂₂H₂₆N₄O₃
• Número CAS: 701232-20-4
• Peso molecular: 394.47
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825541
• NACRES: NA.77
• MDL number: MFCD11977270
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: T863, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 15 mg/mL (clear solution)
• storage temp.: 2-8°C
• SMILES string: CC1(C)Oc2ncnc(N)c2N=C1c3ccc(cc3)[C@@H]4CC[C@H](CC4)CC(O)=O
• InChI: 1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
• InChI key: FUIYMYNYUHVDPT-HDJSIYSDSA-N

Descripción

Application

T863 has been used as a diglyceride acyltransferase (DGAT1) inhibitor:

• to provide the opportunity to precisely control the DGAT inhibition
• to treat mouse embryonic fibroblasts (MEFs) to analyse lipid droplet biogenesis
• to specifically block neutral lipid synthesis and lipid droplet formation in HT-1080 cells
• to block lipid droplet (LD) formation

Biochem/physiol Actions

T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.

T863 is an orally active, selective and potent DGAT1 inhibitor.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable