SML0507

NPC26

≥98% (HPLC)

• Sinónimos: 4,5,6,7-Tetrahydro-5,5,7,7-tetramethyl-2-[[(5-nitro-2-thienyl)carbonyl]amino]-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester, NPC-26
• Fórmula empírica (notación de Hill): C₁₉H₂₃N₃O₅S₂
• Número CAS: 864860-32-2
• Peso molecular: 437.53
• NACRES: NA.77
• PubChem Substance ID: 329825516
• UNSPSC Code: 12352200
• MDL number: MFCD04428321
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: light orange to dark orange
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: CCOC(=O)c1c2CC(C)(C)NC(C)(C)c2sc1NC(=O)c3ccc(s3)[N+]([O-])=O
• InChI: 1S/C19H23N3O5S2/c1-6-27-17(24)13-10-9-18(2,3)21-19(4,5)14(10)29-16(13)20-15(23)11-7-8-12(28-11)22(25)26/h7-8,21H,6,9H2,1-5H3,(H,20,23)
• InChI key: DWGSXNATVAGHKZ-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

NPC26 induces mitochondrial fragmentation and cell death in RAS expressing cells, similar to erastin. The effects of NPC26 are independent of ROS scavengers, which can block cell death induced by erastin.

NPC26 induces mitochondrial fragmentation and cell death in RAS expressing cells.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable