SML0223

Zoledronic acid monohydrate

≥98% (HPLC)

• Sinónimos: P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate, Zoledronate monohydrate, [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate
• Fórmula empírica (notación de Hill): C₅H₁₀N₂O₇P₂·H₂O
• Número de CAS: 165800-06-6
• Peso molecular: 290.10
• Número MDL: MFCD08448695
• Código UNSPSC: 12352204
• ID de la sustancia en PubChem: 329825242
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated; protect from light
• color: white to beige
• solubilidad: H₂O: ≥2 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O.OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
• InChI: 1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2
• Clave InChI: FUXFIVRTGHOMSO-UHFFFAOYSA-N

Descripción

Aplicación

Zoledronic acid monohydrate has been used:

• as an inhibitor for cell proliferation in glioblastoma, breast cancer tumor and prostate cancer cell line LAPC4
• as a conjugate with D,L-lactide 75: glycolide 25 (PLGA) to analyze its bone formation functionality in distal femur
• as an inhibitor for farnesyl diphosphate synthase enzyme in glioblastoma cells

Acciones bioquímicas o fisiológicas

Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget′s disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones.

Zoledronic acid (zoledronate) is a bone resorption inhibitor, an inhibitor of farnesyl diphosphate synthase

Nota de preparación

This product is extremely unstable in solution and should be used shortly after reconstitution. If storage of the solution is necessary it can be held at 2-8ºC for no more than 24 hours.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable