SML0221

Piperlongumine

≥97% (HPLC)

• Sinónimos: 5,6-Dihydro-1-(1-oxo-3-[3,4,5-trimethoxyphenyl]-trans-2-propenyl)-2[1H]-pyridinone, 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-Pyridinone, Piplartin, Piplartine
• Fórmula empírica (notación de Hill): C₁₇H₁₉NO₅
• Número de CAS: 20069-09-4
• Peso molecular: 317.34
• Número MDL: MFCD00075706
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 329825240
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥97% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: ≥5 mg/mL at warmed to 60 °C
• temp. de almacenamiento: 2-8°C
• cadena SMILES: COc1cc(\C=C\C(=O)N2CCC=CC2=O)cc(OC)c1OC
• InChI: 1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+
• Clave InChI: VABYUUZNAVQNPG-BQYQJAHWSA-N

Descripción

Descripción general

Piperlongumine is an alkaloid, which is extracted from Piper longum Linn. It exhibits anti-atherosclerotic, anxiolytic, antidiabetic, antidepressant, antibacterial, anti-platelet, aggregation, anxiolytic and anti-inflammatory properties. Piperlongumine prevents the production of tumor necrosis factor-α and interleukin-6. It blocks the activation of nuclear factor-κB (NF-κB) against proinflammatory responses. Piperlongumine inhibits plaque formation and inhibits vascular smooth muscle cell migration. It is used to treat cough, respiratory infections and stomach-ache.

Aplicación

Piperlongumine has been used to study the regulation of protein regulator of cytokinesis 1 (PRC1) expression. It has also been used to investigate its anti-tumor effects on human melanoma cells in vitro.

Piperlongumine has been used:

• as a pro-oxidant drug to treat HepG2 cells expressing zinc finger protein (ZNF)32
• to test its anti-neuroinflammatory effects in BV2 microglial cells
• to test its inhibitory effect on human gastric cancer cell lines

Acciones bioquímicas o fisiológicas

Piperlongumine is an inhibitor or Glutathione S-transferase pi 1; Apoptosis Inducer in cancer, not normal cells

Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). It increases the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells with little effect on either rapidly or slowly dividing primary normal cells. Piperlongumine showed significant antitumour effects in a variety of mouse tumour models and inhibited growth of spontaneously formed malignant breast tumours and their associated metastases.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable