S4881

Staphylococcal enterotoxin B from Staphylococcus aureus

• Sinónimos: Enterotoxin B, Staphylococcal, SEB
• Número CAS: 11100-45-1
• UNSPSC Code: 12352202
• NACRES: NA.25
• MDL number: MFCD00082017

Propiedades

• contains: sodium phosphate buffer as balance
• Quality Segment: 300
• composition: Protein, ~25% Lowry
• availability: not available in USA
• impurities: Staphylococcal enterotoxin A (SEA), essentially free
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: 2-8°C

Descripción

General description

Staphylococcal Enterotoxin B (SEB) is a potent exotoxin produced by Staphylococcus aureus, classified as a superantigen due to its unique ability to activate T-cells non-specifically. This activation occurs through the cross-linking of T-cell receptors (TCRs) and major histocompatibility complex (MHC) class II molecules, leading to a massive release of cytokines and an exaggerated immune response. SEB is associated with food poisoning and toxic shock syndrome, making it a critical agent for studying the mechanisms of bacterial pathogenesis and immune dysregulation.
In addition to its role in infectious disease research, SEB serves as a valuable tool for investigating autoimmune conditions and the development of immunotherapies. Its ability to induce T-cell activation and proliferation makes it an important reagent for exploring T-cell biology, including differentiation, memory formation, and the effects of various immunomodulators.

Application

Staphylococcal enterotoxin B (SEB) which binds to MHC class II molecules and specific Vβ regions of T cell receptors (TCR), resulting in the activation of both monocytes/macrophages and T lymphocytes may be used as a superantigen and immune system activator. SEB may be used as a reference material in the development of SEB detection systems.

Biochem/physiol Actions

A superantigen for T-lymphocytes. Activator of the immune system that binds to major histocompatibility complex (MHC) antigens and CD28.

Packaging

Package size based on protein content.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H300 + H310 + H330,H315,H319,H335
• pcodes: P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable