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R101

Ranitidine hydrochloride

H2 histamine receptor antagonist;, solid

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A ustedes/SKUDisponibilidadPrecio
1 g
Comprobar disponibilidad del carrito
$40.700
5 g
Comprobar disponibilidad del carrito
$95.400

Acerca de este artículo

Fórmula empírica (notación de Hill):
C13H22N4O3S · HCl
Número CAS:
Peso molecular:
350.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
266-333-0
MDL number:
Form:
solid

$40.700


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Nombre del producto

Ranitidine hydrochloride, solid

form

solid

Quality Segment

color

tan

solubility

H2O: 1.8 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 7.0 mg/mL

originator

GlaxoSmithKline

SMILES string

Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O

InChI

1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;

InChI key

GGWBHVILAJZWKJ-CHHCPSLASA-N

Gene Information

human ... HRH2(3274)

Application

Ranitidine hydrochloride has been used as a reference compound for the development and validation of parallel artificial membrane permeability assay (PAMPA).

Biochem/physiol Actions

H2 histamine receptor antagonist; anti-ulcer agent.
Ranitidine is mainly used to treat gastrointestinal impairment instigated by non-steroidal anti-inflammatory drugs (NSAIDs).

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Este artículo
L109H127T9778
form

solid

form

solid

form

powder

form

solid

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

solubility

H2O: 1.8 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 7.0 mg/mL

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >10 mg/mL, H2O: 10 mg/mL, methanol: 28 mg/mL

solubility

H2O: slightly soluble 1.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >14 mg/mL, ethanol: soluble

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL, ethanol: 5.6 mg/mL, H2O: insoluble

color

tan

color

white

color

white to beige

color

white

Gene Information

human ... HRH2(3274)

Gene Information

human ... CCKAR(886)

Gene Information

human ... CHRM3(1131)

Gene Information

human ... CHRM3(1131), CHRM4(1132)

originator

GlaxoSmithKline

originator

-

originator

-

originator

-


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pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Questions

1–2 of 2 Questions  
  1. Do you have any data on the concentration of NDMA and NDEA in this reagent?

    1 answer
    1. The impurities in this product are not identified. Please see the product specification to view tests performed for this product:
      https://www.sigmaaldrich.com/specification-sheets/583/995/R101-BULK_________SIGMA____.pdf

      Helpful?

  2. こちらのラニチジン塩酸塩中には、不純物としてN-Nitrosodimethylamine (NDMA) 、N-Nitrosodiethylamine (NDEA) は含まれていますでしょうか。また、含まれている場合、その濃度についての情報はありますでしょうか。

    1 answer
    1. The impurities in this product are not identified. Please see the product specification to view the testing performed for this product:
      https://www.sigmaaldrich.com/specification-sheets/583/995/R101-BULK_________SIGMA____.pdf

      Unless otherwise stated this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption or application to humans or animals.

      Helpful?

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