P8727

Palmityl trifluoromethyl ketone

phosholipase A2 inhibitor

• Sinónimos: PACOCF3, Pentadecyl trifluoromethyl ketone
• Fórmula empírica (notación de Hill): C₁₇H₃₁F₃O
• Número CAS: 141022-99-3
• Peso molecular: 308.42
• NACRES: NA.77
• PubChem Substance ID: 329820334
• UNSPSC Code: 12352202
• MDL number: MFCD00797669

Propiedades

• biological source: synthetic (organic)
• assay: ≥98% (TLC)
• form: liquid
• concentration: 10 mg/mL in ethanol
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCCCCCC(=O)C(F)(F)F
• InChI: 1S/C17H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(21)17(18,19)20/h2-15H2,1H3
• InChI key: MAHYXYTYTLCTQD-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

Reversible inhibitor of calcium-dependent phospholipase A₂ (IC₅₀ = 3.8 μM). Unlike other PLA2 inhibitors studied, PACOCF3 at 50 μM induced an increase in intracellular [Ca²⁺], and at 10 μM, enhanced calcium-ion influx induced by ATP and bradykinin.

Información de seguridad

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H225,H319
• pcodes: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Clase de almacenamiento: 3 - Flammable liquids
• wgk: WGK 2
• flash_point_f: 57.2 °F - closed cup
• flash_point_c: 14.0 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Gloves