P6254

Prednisona

≥98% (HPLC), powder, anti-inflammatory activity

• Sinónimos: 1,4-Pregnadieno-17α,21-diol-3,11,20-triona, 1- Cortisona, 17α,21-dihidroxi-1,4-pregnadieno-3,11,20-triona, Dehidrocortisona
• Fórmula empírica (notación de Hill): C₂₁H₂₆O₅
• Número CAS: 53-03-2
• Peso molecular: 358.43
• NACRES: NA.77
• PubChem Substance ID: 24898748
• UNSPSC Code: 12352200
• EC Number: 200-160-3
• MDL number: MFCD00003608
• Beilstein/REAXYS Number: 2065301
• Assay: ≥98%
• Form: powder

Propiedades

• Nombre del producto: Prednisona, ≥98%
• biological source: synthetic
• Quality Segment: 200
• sterility: non-sterile
• assay: ≥98%
• form: powder
• mp: 236-238 °C (lit.)
• solubility: chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to light yellow
• application(s): hematology
• shipped in: ambient
• storage temp.: room temp
• SMILES string: O=C1C=C[C@@]2(C)C(CC[C@]([C@@](CC[C@@]3(C(CO)=O)O)([H])[C@]3(C)C4)([H])[C@]2([H])C4=O)=C1
• InChI: 1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
• InChI key: XOFYZVNMUHMLCC-ZPOLXVRWSA-N
• Gene Information: human ... NR3C1(2908)

Descripción

Application

Prednisone has been used in dimethyl sulfoxide stock suspension to inject into experimental mice and to analyze the effects of glucocorticoid steroid. It has also been used as a test drug, formulated with peanut butter to study the effects of daily administration of MIDD0301, by animal weight, organ weight and haematological analysis.

Biochem/physiol Actions

Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activity. It is useful in treating many disease states and has a half-life of 3.4 to 3.8 hours in plasma. Prednisone is metabolized to prednisolone, which is physiologically active.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS08
• Palabra de advertencia: Warning
• Códigos de peligro: H373
• Indicaciones de precaución: P260 - P314 - P501
• Hazard Classifications: STOT RE 2
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• EPI (equipos de protección individual): Eyeshields, Gloves, type P3 (EN 143) respirator cartridges