P5248

Etidronate disodium hydrate

≥97% (NMR), solid

• Sinónimos: Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate
• Fórmula empírica (notación de Hill): C₂H₆Na₂O₇P₂ · xH₂O
• Número CAS: 7414-83-7
• Peso molecular: 249.99 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 329820220
• UNSPSC Code: 12352200
• EC Number: 231-025-7
• MDL number: MFCD00152567
• Assay: ≥97% (NMR)
• Form: solid

Propiedades

• Quality Segment: 100
• assay: ≥97% (NMR)
• form: solid
• color: white
• mp: >300 °C
• solubility: H₂O: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: [Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O
• InChI: 1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
• InChI key: GWBBVOVXJZATQQ-UHFFFAOYSA-L

Descripción

Application

Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).

Biochem/physiol Actions

Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC₅₀ = 80 μM) as compared to the nitrogen containing bisphosphonates

Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves