N5636

3-Nitropropionic acid

≥97% (HPLC), powder or crystals, mitochondrial complex II inhibitor

• Fórmula lineal: O₂N(CH₂)₂CO₂H
• Número CAS: 504-88-1
• Peso molecular: 119.08
• NACRES: NA.77
• PubChem Substance ID: 24278593
• UNSPSC Code: 12352200
• EC Number: 208-003-0
• MDL number: MFCD00007406
• Beilstein/REAXYS Number: 1759889
• Assay: ≥97%
• Form: powder or crystals

Propiedades

• Nombre del producto: 3-Nitropropionic acid, ≥97%
• biological source: synthetic
• Quality Segment: 100
• assay: ≥97%
• form: powder or crystals
• color: white to light yellow
• mp: 68-70 °C (lit.)
• solubility: alcohol: may be light yellow 100 mg/mL
• storage temp.: 2-8°C
• SMILES string: OC(CC[N+]([O-])=O)=O
• InChI: 1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
• InChI key: WBLZUCOIBUDNBV-UHFFFAOYSA-N

Descripción

Application

3-Nitropropionic acid has been used:

• to generate multiple system atropy-parkinsoniam (MSA-P) model in rat to evaluate its effect on embryonic striatal and mesencephalic grafts
• to inject into the nigrostriatal dopaminergic pathway in rats in order to examine its specific effects on the dopamine system
• as succinate dehydrogenase (SDH) inhibitor for LUHMES neurons and cell lines

Biochem/physiol Actions

Administering 3-nitropropionic acid (3-NP) to the inner ear can stimulate sensorineural hearing loss. It serves as an irreversible inhibitor of mitochondrial complex II.

Excitotoxin shown to cause brain lesions similar to those of Huntington′s disease.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P330 + P331 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges