N5017

Neuropeptide Y human

≥95% (HPLC), powder, synthetic

• Sinónimos: NPY, hNPY
• Fórmula empírica (notación de Hill): C₁₈₉H₂₈₅N₅₅O₅₇S
• Número CAS: 90880-35-6
• Peso molecular: 4271.68
• UNSPSC Code: 12352200
• NACRES: NA.32
• MDL number: MFCD00212432

Propiedades

• biological source: synthetic
• Quality Segment: 200
• assay: ≥95% (HPLC)
• form: powder
• color: white
• solubility: H₂O: 1 mg/mL
• UniProt accession no.: P01303
• storage temp.: −20°C
• SMILES string: S(CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]6N(CCC6)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]7N(CCC7)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]8N(CCC8)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]9N(CCC9)C(=O)[C@@H](N)Cc%10ccc(cc%10)O)CO)C
• InChI: 1S/C189H285N55O57S/c1-15-93(7)148(179(295)234-128(81-140(193)254)168(284)226-123(74-92(5)6)171(287)239-149(94(8)16-2)180(296)240-150(99(13)247)181(297)222-115(31-22-67-208-189(202)203)156(272)220-117(56-59-139(192)253)161(277)218-113(29-20-65-206-187(198)199)157(273)224-121(151(195)267)76-101-38-48-107(249)49-39-101)238-172(288)126(79-104-44-54-110(252)55-45-104)229-167(283)127(80-105-86-204-90-210-105)230-159(275)114(30-21-66-207-188(200)201)219-164(280)122(73-91(3)4)225-154(270)96(10)212-173(289)133(88-245)236-166(282)125(78-103-42-52-109(251)53-43-103)228-165(281)124(77-102-40-50-108(250)51-41-102)227-158(274)112(28-19-64-205-186(196)197)216-152(268)95(9)211-155(271)119(62-72-302-14)221-169(285)130(84-146(263)264)232-162(278)118(58-61-144(259)260)217-153(269)97(11)213-176(292)136-33-24-68-241(136)182(298)98(12)214-163(279)129(83-145(261)262)231-160(276)116(57-60-143(257)258)215-142(256)87-209-175(291)135-32-23-70-243(135)185(301)132(82-141(194)255)235-170(286)131(85-147(265)266)233-177(293)138-35-26-71-244(138)184(300)120(27-17-18-63-190)223-174(290)134(89-246)237-178(294)137-34-25-69-242(137)183(299)111(191)75-100-36-46-106(248)47-37-100/h36-55,86,90-99,111-138,148-150,245-252H,15-35,56-85,87-89,190-191H2,1-14H3,(H2,192,253)(H2,193,254)(H2,194,255)(H2,195,267)(H,204,210)(H,209,291)(H,211,271)(H,212,289)(H,213,292)(H,214,279)(H,215,256)(H,216,268)(H,217,269)(H,218,277)(H,219,280)(H,220,272)(H,221,285)(H,222,297)(H,223,290)(H,224,273)(H,225,270)(H,226,284)(H,227,274)(H,228,281)(H,229,283)(H,230,275)(H,231,276)(H,232,278)(H,233,293)(H,234,295)(H,235,286)(H,236,282)(H,237,294)(H,238,288)(H,239,287)(H,240,296)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H4,196,197,205)(H4,198,199,206)(H4,200,201,207)(H4,202,203,208)/t93-,94-,95-,96-,97-,98-,99+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,148-,149-,150-/m0/s1
• InChI key: XKWCTHKJQNUFOQ-HRPSIEBRSA-N
• Gene Information: human ... NPY(4852)

Descripción

General description

Neuropeptide Y is a regulatory molecule encoded by a gene mapped to human chromosome 7p15. Neuropeptide Y is a 36 amino acid protein with C-terminal α-amide structure. It is ubiquitously distributed in heart and brain, but at high levels in paraventricular hypothalamic nucleus, hypothalamic arcuate nucleus, suprachiasmatic nucleus, median eminence, dorsomedial, hypothalamic nucleus, paraventricular thalamic nuclei. NPY is a member of antimicrobial peptide family, which also include dermaseptins, cecropins or magainins.

Application

Neuropeptide Y (NPY) human has been used:

• to study the effect of antiepileptic effects on pentylenetetrazole (PTZ) rats.
• as a standard in high-performance liquid chromatography (HPLC) standard and control to verify specificity of the antibodies.
• to study the effect of NPY on motor and electroencephalographic (EEG) seizures induced by kainic acid.

Biochem/physiol Actions

Vasoconstrictor; brain peptide that inhibits Ca²⁺-activated K⁺ channels in vascular smooth muscle. Implicated in the control of blood pressure, sexual behavior and food intake. Inhibits cholecystokinin- and secretin-stimulated pancreatic secretion.

Vasoconstrictor; inhibits Ca²⁺-activated K⁺ channels in vascular smooth muscle; inhibits cholecystokinin- and secretin-stimulated pancreatic secretion.

Neuropeptide Y (NPY) plays a vital role in various processes including feeding behaviour, anxiety, epilepsy, circadian, as well as rhythm memory processing, sleep, pain and drug addiction. In addition, it is also implicated in regulation of appetite, body weight and obesity. It controls central endocrine secretion and has potent vasoactive effects on the cardiovascular system. NPY is involved in the pathogenesis of atherosclerosis and coronary artery disease. NPY exhibits antimicrobial activity against Cryptococcus neoformans, Candida albicans and Arthroderma simii.

Other Notes

Lyophilized from 0.1% TFA in H2O

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)