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I5523

Insulin from porcine pancreas

Name: Insulin from porcine pancreas
Brand: SIGMA
Price: 142000 CLP

powder, ≥27 USP units/mg

1 of 2 reviewers received a sample product or took part in a promotion

Sinónimos:

Insulin from hog pancreas

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Talla/SKU	Disponibilidad	Precio
10 mg	Comprobar disponibilidad del carrito	$142.000
50 mg	Comprobar disponibilidad del carrito	$498.000

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Fórmula empírica (notación de Hill):

C₂₅₆H₃₈₁N₆₅O₇₆S₆

Número CAS:

12584-58-6

Peso molecular:

5777.54

UNSPSC Code:

12352202

NACRES:

NA.32

EC Number:

235-703-3

MDL number:

MFCD00131380

Biological source:

Porcine pancreas

Form:

powder

Assay:

≥98%

$142.000

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Propiedades

biological source

Porcine pancreas

Quality Segment

200

sterility

non-sterile

assay

≥98%

form

powder

specific activity

≥27 USP units/mg

technique(s)

cell culture | mammalian: suitable

solubility

0.01 M HCl: 5 mg/mL, clear, colorless

cation traces

Zn: 0.20-0.70%

UniProt accession no.

P01315

shipped in

ambient

storage temp.

−20°C

InChI key

NOESYZHRGYRDHS-ZYCCASTOSA-N

Gene Information

pig ... INS(397415)

Descripción

Application

Insulin from porcine pancreas has been used:

for culturing of the primary tumors obtained from mice and porcine preantral follicles
to characterize hormones involved in postnatal chicken preadipocyte differentiation in vitro
to check the reduction ability of the Escherichia coli thiol disulfide exchange proteins (DsbA, DsbC, DsbG) towards insulin

Biochem/physiol Actions

Regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

Other Notes

InChI: 1S/C256H381N65O76S6/c1-29-131(23)205(313-193(337)104-258)251(391)317-204(130(21)22)247(387)288-159(75-82-200(347)348)217(357)282-156(71-78-189(262)333)221(361)308-183-116-401-402-117-184-242(382)305-178(111-323)239(379)294-162(88-123(7)8)224(364)295-168(95-140-53-61-146(327)62-54-140)227(367)283-154(69-76-187(260)331)218(358)290-161(87-122(5)6)222(362)285-158(74-81-199(345)346)220(360)302-174(101-190(263)334)234(374)298-170(97-142-57-65-148(329)66-58-142)230(370)309-182(241(381)304-176(255(396)397)103-192(265)336)115-400-399-114-181(213(353)272-107-194(338)278-153(72-79-197(341)342)216(356)281-151(51-42-84-270-256(266)267)211(351)271-108-195(339)279-166(93-138-46-36-32-37-47-138)226(366)297-167(94-139-48-38-33-39-49-139)229(369)299-171(98-143-59-67-149(330)68-60-143)237(377)320-208(136(28)326)253(393)321-85-43-52-186(321)245(385)286-152(50-40-41-83-257)214(354)277-134(26)254(394)395)311-249(389)203(129(19)20)316-235(375)164(90-125(11)12)292-228(368)169(96-141-55-63-147(328)64-56-141)296-223(363)160(86-121(3)4)289-209(349)133(25)276-215(355)157(73-80-198(343)344)287-246(386)202(128(17)18)315-236(376)165(91-126(13)14)293-232(372)173(100-145-106-269-120-275-145)301-238(378)177(110-322)280-196(340)109-273-212(352)180(113-398-403-118-185(310-243(183)383)244(384)319-207(135(27)325)252(392)306-179(112-324)240(380)318-206(132(24)30-2)250(390)312-184)307-225(365)163(89-124(9)10)291-231(371)172(99-144-105-268-119-274-144)300-219(359)155(70-77-188(261)332)284-233(373)175(102-191(264)335)303-248(388)201(127(15)16)314-210(350)150(259)92-137-44-34-31-35-45-137/h31-39,44-49,53-68,105-106,119-136,150-186,201-208,322-330H,29-30,40-43,50-52,69-104,107-118,257-259H2,1-28H3,(H2,260,331)(H2,261,332)(H2,262,333)(H2,263,334)(H2,264,335)(H2,265,336)(H,268,274)(H,269,275)(H,271,351)(H,272,353)(H,273,352)(H,276,355)(H,277,354)(H,278,338)(H,279,339)(H,280,340)(H,281,356)(H,282,357)(H,283,367)(H,284,373)(H,285,362)(H,286,385)(H,287,386)(H,288,387)(H,289,349)(H,290,358)(H,291,371)(H,292,368)(H,293,372)(H,294,379)(H,295,364)(H,296,363)(H,297,366)(H,298,374)(H,299,369)(H,300,359)(H,301,378)(H,302,360)(H,303,388)(H,304,381)(H,305,382)(H,306,392)(H,307,365)(H,308,361)(H,309,370)(H,310,383)(H,311,389)(H,312,390)(H,313,337)(H,314,350)(H,315,376)(H,316,375)(H,317,391)(H,318,380)(H,319,384)(H,320,377)(H,341,342)(H,343,344)(H,345,346)(H,347,348)(H,394,395)(H,396,397)(H4,266,267,270)/t131-,132-,133-,134-,135+,136+,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,201-,202-,203-,204-,205-,206-,207-,208-/m0/s1

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Este artículo	1342300	Y0001717	I0516
Sigma-Aldrich I5523 Insulin from porcine pancreas	USP 1342300 Insulin (Pork)	Y0001717 Insulin porcine for system suitability	Sigma-Aldrich I0516 Insulin solution from bovine pancreas
description powder, ≥27 USP units/mg	description United States Pharmacopeia (USP) Reference Standard	description European Pharmacopoeia (EP) Reference Standard	description 10 mg/mL insulin in 25 mM HEPES, pH 8.2, BioReagent, sterile-filtered, suitable for cell culture
biological source Porcine pancreas	biological source -	biological source -	biological source bovine
assay ≥98%	assay -	assay -	assay -
Quality Level 200	Quality Level -	Quality Level -	Quality Level 400
technique(s) cell culture \| mammalian: suitable	technique(s) -	technique(s) -	technique(s) cell culture \| mammalian: suitable, single cell analysis: suitable
form powder	form powder	form -	form solution
Gene Information pig ... INS(397415)	Gene Information -	Gene Information -	Gene Information bovine ... INS(280829) cow ... INS(280829)

Clase de almacenamiento

11 - Combustible Solids

¿Qué está pasando?

WGK 3

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)

Not applicable

EPI (equipos de protección individual)

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

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Dalia
Dalia
Review 1

Votes 0
Charitable Donation

1 out of 5 stars.

Dalia

4 years ago

Easy Loss of Material due to Container and Loss Mass Sold
The twist off cap retains some of the insulin, both on the sides of the screw top and inside the cap top. This meant that it was very difficult to recover 100% of the mass that we purchased. In a 50mg bottle, we only recovered 37mg. This impeded research capabilities and makes the product more expensive than advertised.

A donation to charity was made for this review

Yes
Helpful?
1. Response from Merck KGaA:
  
  Technical Support
  4 years ago
  
  Thank you for reaching out and sharing your review with us. We are sorry to hear about the difficulty in utilizing the product due to the screw top on the 50mg bottle. Your feedback is extremely valuable and has been handed over to our Product Management team for further review and any necessary updates to our product information. Please visit https://www.sigmaaldrich.com/US/en/support/customer-support to submit a Product Technical Inquiry if you need additional support with your issue.
1 Ratings-only review