I5403

Insulin-Like Growth Factor Binding Protein-2 human

recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)

• Sinónimos: IGFBP-2
• UNSPSC Code: 51111800
• NACRES: NA.32
• MDL number: MFCD02099094

Propiedades

• biological source: human
• Quality Segment: 100
• recombinant: expressed in NSO cells
• assay: ≥95% (SDS-PAGE)
• form: lyophilized powder
• potency: 0.04 μg/mL
• mol wt: ~36 kDa by SDS-PAGE, calculated mol wt ~31 kDa
• packaging: pkg of 25 μg
• storage condition: avoid repeated freeze/thaw cycles
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, tested
• UniProt accession no.: P18065
• storage temp.: −20°C
• Gene Information: human ... IGFBP2(3485)

Descripción

General description

The gene IGFBP-2 (insulin-like growth factor binding protein-2) is mapped to human chromosome 2q35.

Biochem/physiol Actions

During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.

Exhibits a 2-10 fold higher affinity for IGF II than for IGF I.

IGFBP-2 (insulin-like growth factor binding protein-2) regulates the function of IGF ligands. IGFBP2 is associated with skeletal muscle cell proliferation and differentiation. It also plays an important role in the differentiation of corneal fibroblast.

Physical form

Lyophilized from a 0.2 μm filtered solution of 30% (v/v) acetonitrile with 0.1% (v/v) TFA

Analysis Note

The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H319,H332
• pcodes: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Eye Irrit. 2
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves