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H7250

Histamine dihydrochloride

≥99% (TLC), powder, endogenous histamine receptor agonist

Sinónimos:

2-(4-Imidazolyl)ethylamine dihydrochloride

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A ustedes/SKUDisponibilidadPrecio
10 mg
Comprobar disponibilidad del carrito
$50.200
10 g
Comprobar disponibilidad del carrito
$97.700
5 g

Disponible para enviar HOYdesdePUDAHUEL

$111.000
25 g
Comprobar disponibilidad del carrito
$196.000

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Fórmula empírica (notación de Hill):
C5H9N3 · 2HCl
Número CAS:
Peso molecular:
184.07
NACRES:
NA.77
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352116
EC Number:
200-298-4
MDL number:
Beilstein/REAXYS Number:
3624116
Assay:
≥99% (TLC)
Form:
powder

$50.200


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Nombre del producto

Histamine dihydrochloride, ≥99% (TLC), powder

Quality Segment

assay

≥99% (TLC)

form

powder

color

white to off-white

mp

249-252 °C (lit.)

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].NCCc1c[nH]cn1

InChI

1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H

InChI key

PPZMYIBUHIPZOS-UHFFFAOYSA-N

Gene Information

General description

Histamine dihydrochloride is a derivative of histamine. It prevents the formation of ROS (reactive oxygen species), which inhibits the activation of T cells and natural killer cells. Histamine dihydrochloride is implicated in tumor cell apoptosis. It prevents the relapse of acute myeloid leukemia in patients.

Application

Histamine dihydrochloride has been used:
  • as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP)
  • to determine its level in fish using HPLC (high performance liquid chromatography)
  • to assess the tracheal response to antigens in guinea-pigs

Biochem/physiol Actions

Endogenous H1 and H2 histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Este artículo
53300H06000001309009
form

powder

form

powder or crystals

form

-

form

-

assay

≥99% (TLC)

assay

≥99.0% (AT)

assay

-

assay

-

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

color

white to off-white

color

-

color

-

color

-

Gene Information

human ... HRH1(3269), HRH2(3274)

Gene Information

human ... HRH1(3269)

Gene Information

human ... HRH1(3269)

Gene Information

human ... HRH1(3269)


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pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves



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Questions

1–6 of 6 Questions  
  1. Is Histamine dihydrochloride H7250 traceable to SI units?

    1 answer
    1. This product is sold by weight. It is a powder that is at least 99% pure. There is no unit value associated with this material. The 'SI' term tends to refer to serum levels as nmol/L.

      To discuss further, please navigate to the link https://www.sigmaaldrich.com/techservice, click on "Product Technical Inquiries" under the Products Section with all the required information so that a member of the Technical Service team can reach out to assist further. Thank you.

      Helpful?

  2. How should Product H7250, Histamine dihydrochloride, be stored?

    1 answer
    1. This product is a powder and should be stored at 2-8°C, dessicated.

      Helpful?

  3. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  4. How should Product H7250, Histamine dihydrochloride, be dissolved?

    1 answer
    1. We test the solubility of this product in water at a concentration of 50 mg/mL. This yields a clear, colorless to faint yellow solution.

      Helpful?

  5. How does the storage temperature relate to shipping conditions?

    1 answer
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Helpful?

  6. What is the solution stablity of Product H7250, Histamine dihydrochloride?

    1 answer
    1. Solutions can be stored at 2-4°C for 8 weeks, and at -20°C for up to 12 months. Once thawed, solutions should be used within 6 hours or discarded. Solutions are light sensitive and need to be protected from light.

      Helpful?

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