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H0540

Anti-Hepatocyte Growth Factor antibody produced in goat

Name: Anti-Hepatocyte Growth Factor antibody produced in goat
Brand: SIGMA

affinity isolated antibody, lyophilized powder

Sinónimos:

Anti-HGF

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About This Item

Número MDL:

MFCD00212968

Código UNSPSC:

51111800

NACRES:

NA.41

origen biológico

goat

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

lyophilized powder

reactividad de especies

mouse

técnicas

capture ELISA: 0.2-0.8 μg/mL
immunohistochemistry: 5-15 μg/mL
western blot: 0.1-0.2 μg/mL

Nº de acceso UniProt

Q08048

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

mouse ... Hgf(15234)

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Inmunógeno

purified, NSO cell-derived recombinant mouse hepatocyte growth factor.

Acciones bioquímicas o fisiológicas

Hepatocyte Growth Factor (HGF) is a multifunctional, heparin-binding factor that stimulates the proliferation of liver cells. The cellular effects of HGF are mediated by its receptor, c-Met, that leads to significant activation of ERK, Src/FAK, STAT3 and PI3K signaling. Various functions of the HGF/c-Met signaling include proliferation, cell survival, motility and adhesion and tissue regeneration. Apart from liver, HGF also mediates regeneration of kidney, lung and gastro-intestines.

Forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Descripción

Precios

Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

SLBB4692V

080M1238

098K0574

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In vivo mitogenic action of HGF on lung epithelial cells: pulmotrophic role in lung regeneration.

H Ohmichi et al.

The American journal of physiology, 270(6 Pt 1), L1031-L1039 (1996-06-01)

Hepatocyte growth factor (HGF) has mitogenic, morphogenic, and motogenic activities on epithelial cells and plays important roles in regeneration of the liver and the kidney. We previously found that the expression of HGF gene is rapidly induced in the lung

The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine.

Toshikazu Nakamura et al.

Proceedings of the Japan Academy. Series B, Physical and biological sciences, 86(6), 588-610 (2010-06-17)

It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor

Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions.

K Matsumoto et al.

Critical reviews in oncogenesis, 3(1-2), 27-54 (1992-01-01)

Hepatocyte growth factor (HGF) is the most potent mitogen for mature hepatocytes and seems to act as a hepatotropic factor that has not been purified over the past 30 years. HGF was first purified from rat platelets in 1986. HGF

HGF as a renotrophic and anti-fibrotic regulator in chronic renal disease.

Shinya Mizuno et al.

Frontiers in bioscience : a journal and virtual library, 13, 7072-7086 (2008-05-30)

Hepatocyte growth factor (HGF) and Met/HGF receptor play roles in dynamic growth and morphogenesis during development and regeneration of organs, including the kidney. In the kidney, HGF targets different types of cells, while its biological actions depend on a target

The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis.

Weon-Kyoo You et al.

BMB reports, 41(12), 833-839 (2009-01-07)

Angiogenesis in tumors is driven by multiple growth factors that activate receptor tyrosine kinases. An important driving force of angiogenesis in solid tumors is signaling through vascular endothelial growth factor (VEGF) and its receptors (VEGFRs). Angiogenesis inhibitors that target this

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