F6889

Famotidine

histamine receptor antagonist

• Sinónimos: N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine
• Fórmula empírica (notación de Hill): C₈H₁₅N₇O₂S₃
• Número CAS: 76824-35-6
• Peso molecular: 337.45
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278442
• NACRES: NA.77
• MDL number: MFCD00079297

Propiedades

• Nombre del producto: Famotidine,
• Quality Segment: 100
• originator: Johnson & Johnson
• SMILES string: N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1
• InChI: 1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
• InChI key: XUFQPHANEAPEMJ-UHFFFAOYSA-N
• Gene Information: human ... HRH2(3274)

Descripción

Application

Famotidine has been used to test its effect on the human ether-a-go-go-related gene (hERG) binding transfected in HEK293 membrane. It has also been used in polycaprolactone based drug delivery studies.

Biochem/physiol Actions

H₂ histamine receptor antagonist; anti-ulcer agent

Famotidine is not effective on muscarinic and nicotinic receptors. It competitively inhibits the secretion of gastric acid and elicits mucosal injury protection.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)