This product is not tested against the USP standard. The unit value is not determined. However, the unit value is closely associated with the purity of the material. An expected value of 40,000,000 units is expected for Cholecalciferol at 100% purity. The minimum purity of this material is 98% which equates to 39.2 million units per gram.
C9756
Colecalciferol
≥98% (HPLC)
Sinónimos:
(+)-Vitamina D3, 7-deshidrocolesterol activado, Activado, 7-deshidrocolesterol, Calciol
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| A ustedes/SKU | Disponibilidad | Precio |
|---|---|---|
1 g | Envío estimado HOYdesdePUDAHUEL | $86.600 |
5 g | Envío estimado HOYdesdePUDAHUEL | $332.000 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C27H44O
Número CAS:
Peso molecular:
384.64
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
34058003
UNSPSC Code:
12352209
EC Number:
200-673-2
MDL number:
Beilstein/REAXYS Number:
2339331
Servicio técnico
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Permítanos ayudarlebiological source
synthetic (organic)
Quality Segment
assay
≥98% (HPLC)
form
powder
technique(s)
HPLC: suitable
color
white to off-white
mp
83-86 °C (lit.)
storage temp.
2-8°C
SMILES string
CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C
InChI
1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
InChI key
QYSXJUFSXHHAJI-YRZJJWOYSA-N
Gene Information
human ... VDR(7421)
General description
Cholecalciferol is sourced either through the diet or exposing skin to ultraviolet rays. Oral administration of vitamin D3 is readily absorbed and is stored in adipose tissue.
Cholecalciferol acts as a hormone precursor since it requires two stages of metabolism: first to 25-hydroxycholecalciferol; then to 1α, 25-dihydroxycholecalciferol. One unit (U.S.P. or international) is defined as the activity of 0.025 μg of vitamin D3 contained in the USP vitamin D reference standard.
Application
- Alterations in regulators of the renal-bone axis, inflammation and iron status in older people with early renal impairment and the effect of vitamin D supplementation.: This study delves into the significant roles of cholecalciferol in modulating the renal-bone axis, inflammatory responses, and iron metabolism in elderly patients with renal impairment. Through vitamin D supplementation, researchers observed pivotal changes that could guide future therapeutic strategies (Christodoulou M et al., 2024).
- Investigating the effects of 25-hydroxyvitamin D3 on clinical outcomes in multiple sclerosis patients: A randomized, double-blind clinical trial- a pilot study.: This clinical trial assesses the efficacy of cholecalciferol in improving the health outcomes of patients with multiple sclerosis. The use of cholecalciferol potentially enhances neurological function and reduces disease progression, illustrating its vital role in neurodegenerative disease management (Maghbooli Z et al., 2024).
- Vitamin D regulates COVID-19 associated severity by suppressing the NLRP3 inflammasome pathway.: This pivotal research links cholecalciferol to the reduction of COVID-19 severity through its regulatory effects on the NLRP3 inflammasome pathway. The findings underscore the potential of vitamin D as a modulatory agent in the immune response against viral infections (Khalil B et al., 2024).
- Effects of Vitamin D Supplementation on Central Hemodynamic Parameters and Autonomic Nervous System in Obese or Overweight Individuals.: This randomized controlled trial explores how cholecalciferol supplementation can affect cardiovascular and autonomic functions in obese or overweight patients, providing insights into its benefits beyond bone health and into cardiovascular regulation (Faria ACC et al., 2024).
Biochem/physiol Actions
Deficiency of vitamin D is often observed in chronic kidney disease.
La Vitamina D actúa a través de un receptor que forma parte de la superfamilia del factor de transcripción dependiente del ligando. Modula la proliferación y diferenciación de las células normales y cancerosas. Tiene efectos contrarios a la proliferación y desarrollo de metástasis en células de cáncer de mama, colon y próstata. Receptores activados de vitamina D en el intestino y los huesos mantienen la absorción de calcio y la homeostasis.
La vitamina D actúa a través de un receptor que modula la proliferación y la diferenciación tanto de las células sanas como de las cancerosas.
Preparation Note
Cholecalciferol C9756 is packaged under argon gas. If it is stored unopened at 2-8°C and protected from light, this product should be stable for a minimum of three years. Unused portions should be stored under nitrogen or argon gas. Deterioration is negligible after storage of one year in amber-evaculated ampules at refrigerator temperatures. It is oxidized and inactivated by moist air within a few days.
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Este artículo | |||
|---|---|---|---|
| technique(s) HPLC: suitable | technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable | technique(s) - | technique(s) - |
| assay ≥98% (HPLC) | assay - | assay ≥97.0% | assay 97.0-103.0% |
| biological source synthetic (organic) | biological source synthetic | biological source synthetic (organic - wool) | biological source - |
| form powder | form solid | form crystalline | form crystalline |
| storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-8°C |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level 200 |
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Clase de almacenamiento
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wgk
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flash_point_f
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flash_point_c
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Hi, how much International Unit does each gram of this product consist?
1 answer-
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Hi Please advise how to make retest for your products C9756-5G Regards
1 answer-
Products are retested according to the schedule set by Quality guidelines. In the case of C9756, the retest occurs every 3 years. Retesting only occurs if ample stock is available of the specific lot. Product retesting is not performed if the batch has sold out, nor is retesting performed upon request. Should stock remain, retesting will be performed near the assigned retest date. Should the lot continue to meet all specifications, the lot retest date is extended and an updated Certificate of Analysis will be generated.
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Dear Sirs, could you please advise the CRM for your product C9756 Lot.No. SLCK8275 and advise the associated uncertainty . Regards
1 answer-
Product PHR1237 is offered as a Certified Reference Material. The product C9756 is not a Certified Reference Material nor is it tested against a CRM. It is intended for research use only. Items that are Certified Reference Materials will be clearly stated as such in the product title as well as the in the "Properties" section.
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I am a professor and researcher from an university in Turkey. We bought your C9756 product for cell culture use. How can we resolve and dilute the product (C9756) for cell culture? Thanks for your help
1 answer-
This material has not been tested in a cell culture application. However, the material can be dissolved in 50 mg/ml of ethanol as mentioned on the Certificate of Analysis.
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