C4042

Captopril

≥98% (HPLC), powder, angiotensin converting enzyme inhibitor

• Sinónimos: N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline
• Fórmula empírica (notación de Hill): C₉H₁₅NO₃S
• Número de CAS: 62571-86-2
• Peso molecular: 217.29
• Beilstein: 477887
• Número CE: 263-607-1
• Número MDL: MFCD00168073
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 57654003
• NACRES: NA.77

Propiedades

• Nombre del producto: Captopril, ≥98% (HPLC), powder
• origen biológico: synthetic
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to off-white
• mp: 104-108 °C (lit.)
• solubilidad: water: 100 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• emisor: Bristol-Myers Squibb
• temp. de almacenamiento: room temp
• cadena SMILES: C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O
• InChI: 1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
• Clave InChI: FAKRSMQSSFJEIM-RQJHMYQMSA-N
• Información sobre el gen: human ... ACE(1636) , AGTR1(185) , AGTR2(186) , ECE1(1889) ; rat ... Ace(24310)

Descripción

Aplicación

Captopril has been used:

• to examine the influence of timing of captopril treatment on efficacy in transverse aortic constriction (TAC) mice
• as an angiotensin-converting enzyme inhibitor and orally administered to unrestrained Wistar Kyoto rats in an approach to study its effects of angiogenesis inhibition and interdependency with other drugs
• used as a positive control in spectrophotometric assay to study the angiotensin-converting enzyme inhibitory activity

Acciones bioquímicas o fisiológicas

Angiotensin converting enzyme inhibitor. Inhibits the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.

Captopril is known to decrease the cardiovascular complications arising due to myocardial infarction. It is an effective drug in treating diabetic nephropathy and renal disease. Captopril acts by reducing cardiac related inflammation, fibrosis and calcification.

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Danger
• Frases de peligro: H341,H360F
• Consejos de prudencia: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Clasificaciones de peligro: Muta. 2 - Repr. 1B
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges