Based on our quality control testing, Corticotropin Releasing Factor human, rat (C3042) is soluble in water at a concentration of 1 mg/ml.
C3042
Corticotropin Releasing Factor human, rat
≥95% (HPLC), powder
Sinónimos:
CRF, CRH
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0.1 MG
$171.000
250 μG
$344.000
0.5 MG
$588.000
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0.1 MG
$171.000
250 μG
$344.000
0.5 MG
$588.000
About This Item
Fórmula empírica (notación de Hill):
C208H344N60O63S2
Número de CAS:
Peso molecular:
4757.45
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.32
Productos recomendados
origen biológico
human
rat
Nivel de calidad
Ensayo
≥95% (HPLC)
Formulario
powder
mol peso
4757.45
condiciones de almacenamiento
(Keep container tightly closed in a dry and well-ventilated place)
técnicas
activity assay: suitable
solubilidad
water: 1.00-1.04 mg/mL, colorless
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Clave InChI
VXFVFWFSJFSXHN-FAUHKOHMSA-N
Información sobre el gen
human ... CRH(1392)
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Amino Acid Sequence
Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2
Descripción general
Aplicación
Corticotropin Releasing Factor human, rat has been used:
- as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants[3]
- as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells[4]
- in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture[5]
- in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus[6]
Acciones bioquímicas o fisiológicas
CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
Corticotropin-releasing factor modulates stress responses.[7][1] It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.[8]Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders.[9] Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.[10]
Releases ACTH and endorphin from the anterior pituitary; central nervous system neurotransmitter.
Otras notas
Lyophilized from 0.1% TFA in H2O
anticuerpo
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Certificados de análisis (COA)
Lot/Batch Number
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Corticotropin-releasing hormone (CRH; previously known as corticotropin-releasing factor) is the central regulator of the hypothalamic-pituitary-adrenal (HPA) axis, which is the main organizer of the body’s response to stress.– Stress induces the hypothalamic production and release of CRH, which then causes
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What is the solubility of Corticotropin Releasing Factor human, rat (C3042)?
1 answer-
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What is the counter ion in Corticotropin Releasing Factor human, rat (C3042)?
1 answer-
Corticotropin Releasing Factor human, rat (C3042) is lyophilized from 0.1% TFA in water.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the difference between the peptide content and the purity of Corticotropin Releasing Factor human, rat (C3042)?
1 answer-
The peptide content of Corticotropin Releasing Factor human, rat (C3042) is determined by amino acid analysis (AAA) and distinguishes how much of the product is actually peptide. The purity of Corticotropin Releasing Factor human, rat (C3042) is determined by HPLC and distinguishes how much of the peptide found is Corticotropin Releasing Factor human, rat (C3042).
Helpful?
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What is the solution stability of Corticotropin Releasing Factor human, rat (C3042)?
1 answer-
Sigma has not tested Corticotropin Releasing Factor human, rat (C3042) for solution stability or for stability in culture. The following article looks at the stability of corticotropin releasing factor: Acta Med Okayama. 1985 Jun;39(3):199-206.
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