C2401

Crotaline

Pulmotoxic, powder

• Sinónimos: (-)-Monocrotaline, Monocrotaline
• Fórmula empírica (notación de Hill): C₁₆H₂₃NO₆
• Número CAS: 315-22-0
• Peso molecular: 325.36
• NACRES: NA.77
• PubChem Substance ID: 24892326
• UNSPSC Code: 12352200
• MDL number: MFCD00084656
• Beilstein/REAXYS Number: 48732
• Form: powder

Propiedades

• Nombre del producto: Crotaline,
• form: powder
• mp: 204 °C (dec.) (lit.)
• storage temp.: 2-8°C
• SMILES string: [H][C@@]12[C@H]3CCN1CC=C2COC(=O)[C@](C)(O)[C@](C)(O)[C@@H](C)C(=O)O3
• InChI: 1S/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/t9-,11+,12+,15+,16-/m0/s1
• InChI key: QVCMHGGNRFRMAD-XFGHUUIASA-N

Descripción

General description

Crotaline is a macrocyclic compound belonging to the pyrrolizidine alkaloid family. It is naturally present in Crotalaria spectabilis.

Application

Crotaline has been used in hydrochloric acid (HCl) and injected into experimental animals to induce-pulmonary hypertension.

Biochem/physiol Actions

Crotaline induces pulmonary vascular syndrome in rats. It is considered toxic and results in hepatic cirrhosis, enlarged liver, sinusoidal obstruction syndrome and right ventricular hypertrophy.Monocrotaline is known to inhibit the growth of various experimental tumors.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de advertencia: Danger
• Códigos de peligro: H301,H351
• Indicaciones de precaución: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 2
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• ¿Qué está pasando?: WGK 1
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges