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B7283

Sigma-Aldrich

Benserazide hydrochloride

≥98% (HPLC), solid, L-aromatic amino acid decarboxylase inhibitor

Sinónimos:

DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C10H15N3O5 · HCl
Número de CAS:
14919-77-8
Peso molecular:
293.70
EC Number:
238-991-9
MDL number:
MFCD00078571
UNSPSC Code:
12352125
PubChem Substance ID:
24277886
NACRES:
NA.77

product name

Benserazide hydrochloride, ≥98% (HPLC), solid

biological source

synthetic

assay

≥98% (HPLC)

form

solid

solubility

H2O: 10 mg/mL

originator

Roche

storage temp.

room temp

SMILES string

Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O

InChI

1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H

InChI key

ULFCBIUXQQYDEI-UHFFFAOYSA-N

Gene Information

human ... DDC(1644)

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General description

Benserazide is a peripheral decarboxylase inhibitor.

Application

Benserazide has been used:
  • to inhibit dopa-decarboxylase
  • to induce dyskinesia
  • to test on purified bacterial TDCs to assess the extent to which it could affect bacterial decarboxylases
  • as a peripheral dopa decarboxylase inhibitor to treat mice

Biochem/physiol Actions

Benserazide can block HK2 enzymatic activity in vitro. It is used along with levodopa to treat Parkinson′s disease.
Inhibitor of L-aromatic amino acid decarboxylase.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Restoration of the dopamine transporter through cell therapy improves dyskinesia in a rat model of Parkinson?s Disease
Tomas D, et al.
PLoS ONE, 11(4), e0153424-e0153424 (2016)
24 - Extrapyramidal movement disorders and spasticity
Waller DG, et al.
Medical Microbiology, 325-336 (2018)
Developmental and evolutionary basis for drought tolerance of the Anopheles gambiae embryo
Goltsev Y, et al.
Developmental Biology, 330(2), 462-470 (2009)
Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine
Tillerson JL, et al.
Experimental Neurology, 178, 80-90 (2002)
Diana Matheoud et al.
Nature, 571(7766), 565-569 (2019-07-19)
Parkinson's disease is a neurodegenerative disorder with motor symptoms linked to the loss of dopaminergic neurons in the substantia nigra compacta. Although the mechanisms that trigger the loss of dopaminergic neurons are unclear, mitochondrial dysfunction and inflammation are thought to
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