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93482

Sigma-Aldrich

Phenylmethanesulfonyl fluoride solution

~0.1 M in ethanol (T)

Sinónimos:

Benzylsulfonyl fluoride, PMSF

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50 ML
$113.000
250 ML
$450.000

$113.000

Fecha estimada de envío17 de abril de 2025

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50 ML
$113.000
250 ML
$450.000

About This Item

Número de CAS:
329-98-6
Beilstein/REAXYS Number:
2088311
MDL number:
MFCD00007424
UNSPSC Code:
12352202
PubChem Substance ID:
57653563
NACRES:
NA.77

$113.000

Fecha estimada de envío17 de abril de 2025

biological source

microbial
synthetic

Quality Level

200

form

liquid

concentration

~0.1 M in ethanol (T)

density

0.797 g/mL at 20 °C

storage temp.

2-8°C

SMILES string

FS(=O)(=O)Cc1ccccc1

InChI

1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2

InChI key

YBYRMVIVWMBXKQ-UHFFFAOYSA-N

Application

Phenylmethanesulfonyl fluoride solution has been used as a component in the cell lysate buffer in breast adenocarcinoma cell line[1], fibrosarcoma cell line[2] and D5 hindbrain and spinal cord neural progenitors.[3]

Biochem/physiol Actions

Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.[4]
Phenylmethanesulfonyl fluoride (PMSF) is a serine protease inhibitor. It binds covalently to active site residue of proteases and prevents proteolytic activity. PMSF is used in cell lysate buffers during protein purification to prevent target protein degradation.[5] PMSF effectively inhibits the naloxone-precipitated withdrawal jumping.[6]

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

53.6 °F - closed cup

flash_point_c

12 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificados de análisis (COA)

Lot/Batch Number
BCCM0399
BCCL2616
BCCL1411
BCCK3515
BCCH5056

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DNA-encoded library-derived DDR1 inhibitor prevents fibrosis and renal function loss in a genetic mouse model of Alport syndrome
Richter H, et al.
ACS Chemical Biology (2018)
Nervous system regionalization entails axial allocation before neural differentiation
Metzis V, et al.
Cell, 175(4), 1105-1118 (2018)
SREBP1 drives KRT80-dependent cytoskeletal changes and invasive behavior in endocrine resistant ERalpha breast cancer
Magnani L, et al.
bioRxiv, 380634-380634 (2018)
C Pinsky et al.
Life sciences, 31(12-13), 1193-1196 (1982-09-20)
Intraperitoneal (IP) injection of the serine proteinase inhibitor phenylmethylsulfonyl fluoride (PMSF) produced dose-dependent analgesia in Sprague-Dawley rats. AD50 was 2.9 +/- 1.4 (S.E.) mg kg-1, the analgesia was antagonized by naloxone but unaffected by atropine. PMSF significantly enhanced the analgesic
Phenylmethanesulfonyl fluoride, a serine protease inhibitor, suppresses naloxone-precipitated withdrawal jumping in morphine-dependent mice
Nemoto W, et al.
Neuropeptides, 47(3), 187-191 (2013)
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Questions

1–4 of 4 Questions  

  1. Is this product 93482 RNase-free?

    1 answer

    1. This product is not tested for RNase activity. Currently, an RNAse tested PMSF product is not available.

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  2. How can I further dilute Product 93482, Phenylmethanesulfonyl fluoride solution?

    1 answer

    1. We would recommend that you use an anhydrous ethanol to further dilute this solution, since PMSF is very unstable in water.

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  3. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  4. What can Product 93482, Phenylmethanesulfonyl fluoride solution, be used for?

    1 answer

    1. PMSF is a serine protease inhibitor, inhibiting the activity of enzymes such as thrombin, trypsin, papain, chymotrypsin and proteinase K. It also inhibits mammalian acetylcholinesterases.

      Helpful?

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