93482

Phenylmethanesulfonyl fluoride solution

~0.1 M in ethanol (T)

• Sinónimos: Benzylsulfonyl fluoride, PMSF
• Número CAS: 329-98-6
• UNSPSC Code: 12352202
• NACRES: NA.77
• PubChem Substance ID: 57653563
• MDL number: MFCD00007424
• Beilstein/REAXYS Number: 2088311

Propiedades

• Quality Segment: 200
• biological source: microbial, synthetic
• form: liquid
• concentration: ~0.1 M in ethanol (T)
• input: general use sample(s)
• density: 0.797 g/mL at 20 °C
• storage temp.: 2-8°C
• SMILES string: FS(=O)(=O)Cc1ccccc1
• InChI: 1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
• InChI key: YBYRMVIVWMBXKQ-UHFFFAOYSA-N

Descripción

Application

Phenylmethanesulfonyl fluoride solution has been used as a component in the cell lysate buffer in breast adenocarcinoma cell line, fibrosarcoma cell line and D5 hindbrain and spinal cord neural progenitors.

Biochem/physiol Actions

Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.

Phenylmethanesulfonyl fluoride (PMSF) is a serine protease inhibitor. It binds covalently to active site residue of proteases and prevents proteolytic activity. PMSF is used in cell lysate buffers during protein purification to prevent target protein degradation. PMSF effectively inhibits the naloxone-precipitated withdrawal jumping.

Información de seguridad

• Pictogramas: GHS02,GHS07
• Palabra de advertencia: Danger
• Códigos de peligro: H225,H315,H319
• Indicaciones de precaución: P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2
• Clase de almacenamiento: 3 - Flammable liquids
• ¿Qué está pasando?: WGK 2
• Punto de inflamación (°F): 53.6 °F - closed cup
• Punto de inflamación (°C): 12 °C - closed cup
• EPI (equipos de protección individual): Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter