19176

DL-Buthionine-sulfoximine

synthetic, ≥99.0% (TLC), glutathione biosynthesis inhibitor, powder or crystals

• Sinónimos: DL-Buthionine (S,R)-sulfoximine, BSO, Buthionine sulfoximine, Butionine sulfoximine
• Fórmula empírica (notación de Hill): C₈H₁₈N₂O₃S
• Número CAS: 5072-26-4
• Peso molecular: 222.31
• NACRES: NA.77
• PubChem Substance ID: 57647786
• UNSPSC Code: 12352202
• MDL number: MFCD00070309
• Beilstein/REAXYS Number: 2367136

Propiedades

• Nombre del producto: DL-Buthionine-sulfoximine, ≥99.0% (TLC)
• biological source: synthetic
• Quality Segment: 100
• assay: ≥99.0% (TLC)
• form: powder or crystals
• mp: 215 °C
• solubility: H₂O: 50 mg/mL, clear to almost clear, colorless
• storage temp.: 2-8°C
• SMILES string: CCCCS(=N)(=O)CCC(N)C(O)=O
• InChI: 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
• InChI key: KJQFBVYMGADDTQ-UHFFFAOYSA-N

Descripción

Application

DL-Buthionine-sulfoximine is suitable for use to:

• examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
• investigate the effect of BSO on development of bovine embryos
• inhibit GSH in several studies
• investigate the effect of GSH synthesis on oocyte maturation

It may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH

Biochem/physiol Actions

DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).

Other Notes

Depletes glutathionine in isolated cells

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H315,H319,H335
• Indicaciones de precaución: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos diana: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): dust mask type N95 (US), Eyeshields, Gloves