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15205

Sigma-Aldrich

Blasticidina S hydrochloride

Blasticidine S hydrochloride

Sinónimos:

Blasticidina S

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25 MG
$215.000
100 MG
$591.000

$215.000

Fecha estimada de envío17 de mayo de 2025

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25 MG
$215.000
100 MG
$591.000

About This Item

Fórmula empírica (notación de Hill):
C17H26N8O5 · HCl
Número de CAS:
3513-03-9
Peso molecular:
458.90
Número MDL:
MFCD02091640
Código UNSPSC:
51102829
ID de la sustancia en PubChem:
57647341
NACRES:
NA.76

$215.000

Fecha estimada de envío17 de mayo de 2025

Solicitar un pedido a granel

Formulario

powder

Nivel de calidad

200

color

white to off-white

solubilidad

acetic acid: water: soluble, clear, colorless

espectro de actividad antibiótica

fungi

aplicaciones

agriculture
environmental

Modo de acción

protein synthesis | interferes

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

cadena SMILES

Cl[H].CN(CC[C@@H](N)CC(=O)N[C@H]1C=C[C@@H](O[C@@H]1C(O)=O)N2C=CC(N)=NC2=O)C(N)=N

InChI

1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10+,13-,14+;/m1./s1

Clave InChI

YQXYQOXRCNEATG-ZAYJLJTISA-N

Descripción general

Estructura química: nucleósido
La blasticidina S pertenece a la clase de antibióticos aminoacilnucleósidos. Inhibe la síntesis de proteínas en bacterias y eucariotas.[1] También tiene propiedades fungicidas y evita la enfermedad del añublo del arroz.[2]

Aplicación

La blasticidina S se utiliza como un agente de selección para las células transformadas que contienen los genes de resistencia bls, bsr o BSD. La blasticidina S se ha utilizado para seleccionar células HEK293-T con construcciones TLR-2 y células HEK-D5[3][4]. También se utiliza para estudiar la síntesis de proteínas al nivel de la formación del enlace peptídico.

Acciones bioquímicas o fisiológicas

La blasticidina S inhibe la hidrólisis del peptidil-ARNt inducida por factores de liberación. Potencia la unión del ARNt a la subunidad grande de los ribosomas y hasta cierto punto inhibe la formación del enlace peptídico.[1]

Envase

Frasco de vidrio sin fondo. El contenido está en el interior del cono fundido insertado.

Otras notas

Mantenga el recipiente herméticamente cerrado y en un lugar bien ventilado. Consérvese en un lugar seco. Clase de almacenamiento (TRGS 510): Materiales peligrosos muy tóxicos, no combustibles, toxicidad aguda cat. 1 y 2

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Referencia del producto
Descripción
Precios

06693

Timestrip Plus™ -20 °C

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H300

Clasificaciones de peligro

Acute Tox. 1 Oral

Código de clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
0000377942
0000377943
0000377942
0000377943
0000228725

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Visite la Librería de documentos

Egor Svidritskiy et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(30), 12283-12288 (2013-07-05)
The antibiotic blasticidin S (BlaS) is a potent inhibitor of protein synthesis in bacteria and eukaryotes. We have determined a 3.4-Å crystal structure of BlaS bound to a 70S⋅tRNA ribosome complex and performed biochemical and single-molecule FRET experiments to determine
Elizabeth J Meredith et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(36), 13485-13490 (2006-08-30)
Human B lymphocytes and derived lines from a spectrum of B cell malignancy were studied for expression of dopaminergic pathway components and for their cytostatic response to the catecholamine and related, potentially therapeutic compounds. Proliferating normal lymphocytes and dividing malignant
James M Burke et al.
Molecular cell, 75(6), 1203-1217 (2019-09-09)
In response to foreign and endogenous double-stranded RNA (dsRNA), protein kinase R (PKR) and ribonuclease L (RNase L) reprogram translation in mammalian cells. PKR inhibits translation initiation through eIF2α phosphorylation, which triggers stress granule (SG) formation and promotes translation of
Rohini Garg et al.
Journal of immunology (Baltimore, Md. : 1950), 184(11), 5980-5987 (2010-05-05)
Vi capsular polysaccharide is a major virulence determinant of the human typhoid- causing pathogen Salmonella typhi; it is absent in nontyphoidal Salmonella serovars. We show in this study that through its specific interaction with the membrane recognition complex containing the
Zhihua Chen et al.
Development (Cambridge, England), 147(18) (2020-09-09)
The central nervous system (CNS) contains a complex network of blood vessels that promote normal tissue development and physiology. Abnormal control of blood vessel morphogenesis and maturation is linked to the pathogenesis of various neurodevelopmental diseases. The CNS-specific genes that
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Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. How should aqueous solutions of Product 15205, Blasticidine S hydrochloride, be stored?

    1 answer

    1. Aqueous solutions of Blasticidine S hydrochloride should be stored in aliquots at -20°C.  Aqueous solutions at a pH °C or for 6 to 8 weeks at -20°C.  Avoid alkaline pH, and do not subject solutions to freeze-thaw cycles.

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  4. What is Product 15205, Blasticidine S hydrochloride, soluble in?

    1 answer

    1. Blasticidine S hydrochloride should be soluble in water at a concentration of 5 - 10 mg/mL. It is also soluble in acetic acid (concentration not reported).

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  5. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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