100-05A

Human Dermal Microvascular Endothelial Cells: CADMEC/HMVEC, adult

• NACRES: NA.81
• UNSPSC Code: 41106514
• Biological source: human neonatal foreskin or adult skin capillaries (normal)
• Growth mode: Adherent
• Morphology: Endothelial

Propiedades

• biological source: human neonatal foreskin or adult skin capillaries (normal)
• packaging: pkg of 500,000 cells
• manufacturer/tradename: Cell Applications, Inc
• growth mode: Adherent
• karyotype: 2n = 46
• morphology: Endothelial
• technique(s): cell culture | mammalian: suitable
• shipped in: dry ice
• storage temp.: −196°C

Descripción

General description

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CADMEC/HMVEC provide an excellent model system to study many aspects of endothelial function and disease, especially those related to the microvasculature and capillary systems. HMVEC/CADMEC have been shown to express vWF, CD36 and CD31, are able to uptake DiI-Ac-LDL and are positive for functional activity by cytokine-stimulated leukocyte adherence.

Select HMVEC lots have been additionally tested to demonstrate stimulation-dependent angiogenesis and key endothelial cell signaling pathways (phosphorylation of VEGFR, Akt, MAPK, and expression of Tie2, eNOS, Axl and Etk/Bmx).

Application

Endothelial vessel function, cell signaling, angiogenesis

Biochem/physiol Actions

Skin

Preparation Note

• 2nd passage, >500,000 cells in Cell Basal Medium containing 10% FBS & 10% DMSO
• Can be cultured at least 16 doublings

Please refer to the CADMEC/HMVEC Culture Protocol.

Other Notes

Cell Basal Medium containing 10% FBS & 10% DMSO

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable