901990

Tetrazine-acid

• Sinónimos: 4-(1,2,4,5-Tetrazin-3-yl)benzeneacetic acid
• Fórmula empírica (notación de Hill): C₁₀H₈N₄O₂
• Número CAS: 1380500-92-4
• Peso molecular: 216.20
• UNSPSC Code: 12352106
• NACRES: NA.22
• MDL number: MFCD24503098

Propiedades

• form: powder or crystals
• availability: available only in USA
• storage temp.: −20°C
• SMILES string: n1ncnnc1c2ccc(cc2)CC(=O)O
• InChI: 1S/C10H8N4O2/c15-9(16)5-7-1-3-8(4-2-7)10-13-11-6-12-14-10/h1-4,6H,5H2,(H,15,16)
• InChI key: SLJKKTFIAUAYGR-UHFFFAOYSA-N

Descripción

Application

Tetrazine-acid demonstrates exceptionally fast cycloaddition kinetics with trans-cyclooctene (TCO) as the dienophile (up to 30,000 M^-1 s^-1). These have been the fastest kinetics reported for a bio orthogonal reaction. The chemical stability of tetrazines is substantially lower compared to methyltetrazines, thus requiring more careful selection of reagents and conditions for chemical transformation. However, tetrazine chemistry is still in an acceptable range for many applications.

Información de seguridad

• pictograms: GHS02
• signalword: Danger
• hcodes: H242
• pcodes: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Clase de almacenamiento: 5.2 - Organic peroxides and self-reacting hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable