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Merck

01518

Supelco

Ginsenoside Rd

analytical standard

Sinónimos:

(3β,12β)-20-(β-D-Glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside, Gypenoside VIII

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About This Item

Fórmula empírica (notación de Hill):
C48H82O18
Número de CAS:
Peso molecular:
947.15
EC Number:
UNSPSC Code:
85151701
NACRES:
NA.24

grade

analytical standard

Quality Level

assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

C\C(C)=C/CC[C@](C)(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]2CC[C@]3(C)[C@@H]2[C@H](O)C[C@@H]4[C@@]5(C)CC[C@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)C(C)(C)[C@@H]5CC[C@@]34C

InChI

1S/C48H82O18/c1-21(2)15-22(3)17-48(8,66-43-40(60)37(57)34(54)28(19-50)62-43)24-11-13-47(7)23-9-10-30-45(4,5)31(12-14-46(30,6)25(23)16-26(52)32(24)47)64-44-41(38(58)35(55)29(20-51)63-44)65-42-39(59)36(56)33(53)27(18-49)61-42/h15,22-44,49-60H,9-14,16-20H2,1-8H3/t22?,23?,24-,25?,26-,27+,28+,29+,30?,31?,32+,33+,34+,35+,36-,37-,38-,39+,40+,41+,42-,43-,44-,46+,47+,48-/m0/s1

InChI key

IRBVCFDYIGGFFY-ADSMOORZSA-N

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General description

Ginsenoside is a steroid-like molecular component having gonane steroid nucleus along with different sugar moieties attached to them found in the roots of Panax ginseng. Ginsenoside Rd is the main active component of ginsenosides, having the ability to inhibit Ca2+ influx through receptors and store-operated Ca2+ channel. From neural stem cells, it is seen to enhance astrocyte differentiation. It also reduces the 3-nitropropionic acid-induced motor impairment and cell loss in stratum. It constitutes to one of the major ingredient in total saponin content from Panax notoginseng.

Application

It was used as reference standard in UPLC/TOF-MS analysis of human plasma to determine Ginsenoside metabolites.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

This compound is commonly found in plants of the genus: panax

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Jie Li et al.
European journal of pharmacology, 652(1-3), 104-110 (2010-12-03)
Recently, it was revealed that the dysfunction of transmembrane Ca(2+) transport, results in an increase in intracellular Ca(2+)[Ca(2+)](i), which is involved in the process of atherosclerosis. We previously demonstrated that ginsenoside-Rd, a purified component from panax notoginseng, is a voltage-independent
Li Wang et al.
The Journal of surgical research, 176(1), 267-274 (2011-08-30)
Organ transplantation is a life-saving procedure for patients with organ failure. However, the side effects of long-term application of classic immunosuppressant remain major obstacles for successful transplantation. Therefore, new and safe immunosuppressive drugs against acute and chronic rejection are eagerly
X Liu et al.
European journal of neurology, 19(6), 855-863 (2012-01-12)
Ginsenoside-Rd is a receptor-operated calcium channel antagonist and has shown promise as a neuroprotectant in our phase II study. As an extended work, we sought to confirm its efficacy and safety of Ginsenoside-Rd in patients with acute ischaemic stroke. We
R Ye et al.
Neuroscience, 178, 169-180 (2011-01-12)
We previously found that ginsenoside Rd (Rd), one of the major active ingredients in Panax ginseng, protects neuronal cells from hydrogen peroxide and oxygen-glucose deprivation, an in vitro model of cerebral ischemia. In this study, we examined the protective effects
Ruidong Ye et al.
Expert review of neurotherapeutics, 13(6), 603-613 (2013-06-07)
Numerous studies have identified pathophysiological mechanisms of acute ischemic stroke and have provided proof-of-principle evidence that strategies designed to impede the ischemic cascade, namely neuroprotection, can protect the ischemic brain. However, the translation of these therapeutic agents to the clinic

Artículos

Optimize HPLC method for ginsenoside separation using a mixture, applying it to American Ginseng root, with conditions and chromatograms shown.

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