8.55098
(3-Formylindolyl)acetamidomethyl polystyrene
Novabiochem®
Iniciar sesión para ver los precios por organización y contrato.
Seleccione un Tamaño
Cambiar Vistas
Acerca de este artículo
NACRES:
NA.22
UNSPSC Code:
13111023
Form:
beads
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarleQuality Segment
product line
Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
aldehyde
storage temp.
2-8°C
General description
Versatile indole-based linker for the synthesis of secondary amides, carbamates, ureas [1,2,3,4] and aminopurines [5]. In a study comparing the cleavage rates of secondary amides, ureas, carbamates and sulfonamides from indole, dialkoxybenzaldehyde and Rink amide resins, the indole resin was found to be the most acid-labile [6].Reductive amination with excess of amine and NaBH(OAc)3 in DCE/TMOF [seepage], NaBH3CN in THF/TMOF/AcOH, or NaBH4-Ti(OiPr)4 in THF [2], converts the formyl group to the appropriate secondary amine. Cleavage can be effected with 2-5% TFA in DCM, depending on the nature of the product being released from the resin.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] K. G. Estep, et al. (1998) J. Org. Chem., 63, 5300.
[2] S. Bhattacharyya, et al. (2003) Tetrahedron Lett., 44, 6099.
[3] N. Hone, et al. (2003) Tetrahedron Lett., 44, 8169.
[4] L. Sereni, et al. (2004) Tetrahedron, 60, 8561.
[5] P. H. Dorff and R. S. Garigipati (2001) Tetrahedron Lett., 42, 2771.
[6] B. Yan, et al. (2000) J. Comb. Chem., 2, 66.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] K. G. Estep, et al. (1998) J. Org. Chem., 63, 5300.
[2] S. Bhattacharyya, et al. (2003) Tetrahedron Lett., 44, 6099.
[3] N. Hone, et al. (2003) Tetrahedron Lett., 44, 8169.
[4] L. Sereni, et al. (2004) Tetrahedron, 60, 8561.
[5] P. H. Dorff and R. S. Garigipati (2001) Tetrahedron Lett., 42, 2771.
[6] B. Yan, et al. (2000) J. Comb. Chem., 2, 66.
Analysis Note
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined by elemental analysis of sulfur after coupling with tosylhydrazide): 0.60 - 1.20 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene-1% DVB), 100 - 200 mesh
Appearance of substance (visual): beads
Loading (determined by elemental analysis of sulfur after coupling with tosylhydrazide): 0.60 - 1.20 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene-1% DVB), 100 - 200 mesh
Other Notes
Replaces: 01-64-0361
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Clase de almacenamiento
11 - Combustible Solids
¿Qué está pasando?
WGK 1
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
Elija entre una de las versiones más recientes:
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.