8.51085

COMU

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

• Sinónimos: COMU, 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino-morpholino)] uronium hexafluorophosphate
• Fórmula empírica (notación de Hill): C₁₂H₁₉F₆N₄O₄P
• Número de CAS: 1075198-30-9
• Peso molecular: 428.27
• Número MDL: MFCD11975052
• Código UNSPSC: 12352107
• NACRES: NA.22

Propiedades

• Nombre del producto: COMU, 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy) dimethylaminomorpholino)] uronium hexafluorophosphate Novabiochem^®
• Nivel de calidad: 300
• Línea del producto: Novabiochem^®
• Ensayo: ≥99.0% (HPLC)
• Formulario: powder
• idoneidad de la reacción: reaction type: Coupling Reactions
• fabricante / nombre comercial: Novabiochem^®
• mp: >140 °C
• aplicaciones: peptide synthesis
• temp. de almacenamiento: 15-25°C
• cadena SMILES: F[P-](F)(F)(F)(F)F.N1(CCOCC1)C(=[O+]\N=C(/C(=O)OCC)\C#N)N(C)C
• InChI: 1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;
• Clave InChI: GPDHNZNLPKYHCN-DZOOLQPHSA-N

Descripción

Descripción general

COMU is a novel reagent which mediates coupling reactions with efficiencies comparable to HATU ^[1,2].It has higher solubility than HATU and HBTU. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents. Recently, the application of COMU in the preparation of esters has been demonstrated ^[3].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] A. El-Faham, et al. (2009) Chem. Eur. J., 15, 9404.
^[2] A. El-Faham & F. Albericio (2010) J. Pept. Sci., 16, 6.
^[3] Jean-d′Amour, et al. (2011) Org. Lett., 13, 2988.

Aplicación

• Re-evaluating the stability of COMU in different solvents: This study highlights the robust stability and effectiveness of COMU, promoting its use in various peptide synthesis scenarios, enhancing both scalability and environmental friendliness (Kumar et al., 2017).

Nota de análisis

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (10% in acetonitrile): clear

Información legal

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable