8.22339

Phosphoryl chloride

for synthesis

• Sinónimos: Phosphoryl chloride, Phosphorus oxide trichloride, Phosphorus oxychloride
• Número CAS: 10025-87-3
• Peso molecular: 153.33
• UNSPSC Code: 12352101
• EC Index Number: 233-046-7
• NACRES: NA.22
• MDL number: MFCD00011443
• Assay: ≥99.0% (argenometric)
• Grade: synthesis grade
• Bp: 105.3 °C/1013 hPa
• Vapor pressure: 36 hPa ( 20 °C)

Propiedades

• grade: synthesis grade
• Quality Segment: 200
• vapor pressure: 36 hPa ( 20 °C)
• assay: ≥99.0% (argenometric)
• form: liquid
• potency: 36 mg/kg LD₅₀, oral (Rat)
• reaction suitability: reaction type: Halogenations
• dilution: (for synthesis)
• pH: 1.0 (25 °C, 5 g/L in H₂O)
• bp: 105.3 °C/1013 hPa
• mp: 1-2 °C
• density: 1.68 g/cm³ at 20 °C (DIN 51757)
• storage temp.: 2-30°C
• SMILES string: [P](=O)(Cl)(Cl)Cl
• InChI: 1S/Cl3OP/c1-5(2,3)4
• InChI key: XHXFXVLFKHQFAL-UHFFFAOYSA-N

Descripción

General description

for synthesis

Application

Phosphoryl chloride is a strong Lewis acid that can be used as:

• A phosphorylating agent for the selective phosphorylation of alcohols, amines, and thiols.
• A dehydrating agent for alcohols, amides, and cyanohydrins.
• A reagent to synthesize Vilsmeier reagent for Vilsmeier-Haack formylation reactions.
• A chlorinating agent for the chlorination of heterocyclic compounds.
• A reagent to prepare dihydroisoquinolines and isoquinolines by cyclization of N-β-phenylethyl amides via Bischler-Napieralski reaction.

Analysis Note

Assay (argentometric)≥ 99.0 %Density (d 20 °C/ 4 °C)1.673 - 1.677Identity (IR)passes test

Información de seguridad

• Pictogramas: GHS06,GHS08,GHS05
• Palabra de advertencia: Danger
• Códigos de peligro: H302,H314,H330,H372
• Indicaciones de precaución: P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1 - STOT RE 1 Inhalation
• Órganos diana: Respiratory Tract
• supp_hazards: EUH014,EUH029
• Clase de almacenamiento: 6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable