567570

Spectinomycin, Dihydrochloride, Pentahydrate, Streptomyces sp.

broad spectrum aminoglycoside antibiotic, solid

• Sinónimos: Spectinomycin, Dihydrochloride, Pentahydrate, Streptomyces sp.
• Fórmula empírica (notación de Hill): C₁₄H₂₄N₂O₇ · 2HCl · 5H₂O
• Número CAS: 22189-32-8
• Peso molecular: 495.35
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00150886
• Form: solid

Propiedades

• Nombre del producto: Spectinomycin, Dihydrochloride, Pentahydrate, Streptomyces sp., A broad spectrum aminoglycoside antibiotic that contains two glucose moieties. Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure.
• Quality Segment: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• color: white to off-white
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [Cl-].[Cl-].[N+H2]([C@@H]1[C@H]2O[C@@]3([C@H](O[C@@H]2[C@H]([C@@H]([C@@H]1O)[N+H2]C)O)O[C@@H](CC3=O)C)O)C.O.O.O.O.O
• InChI: 1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1
• InChI key: DCHJOVNPPSBWHK-UXXUFHFZSA-N

Descripción

General description

A broad spectrum aminoglycoside antibiotic that contains two glucose moieties. Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure. A resistance gene (aph) which encodes a spectinomycin has been cloned from Legionella pneumophila (disease agent for Legionnaire’s disease) kinase and expressed in E. coli. Potency: ≥500 µg/mg.

Biochem/physiol Actions

Primary Target
Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure

Other Notes

Thompson, P.R., et al. 1998. J. Biol. Chem. 273, 14788.
Noah, J., and Wollenzien, P. 1997. Nucleic Acids Symp. Ser. 36, 178.
Suter, T.M., et al. 1997. Antimicrob. Agents Chemother. 41, 1385.
Thom, G., and Prescott, C.D. 1997. Bioorg. Med. Chem. 5, 1081.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H315,H319,H335
• Indicaciones de precaución: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos diana: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 2
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable