516481-M

Pepstatin A, Synthetic

Pepstatin A, Synthetic, CAS 26305-03-3, is a reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin.

• Sinónimos: Pepstatin A, Synthetic, Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
• Fórmula empírica (notación de Hill): C₃₄H₆₃N₅O₉
• Número CAS: 26305-03-3
• Peso molecular: 685.89
• UNSPSC Code: 12352202
• NACRES: NA.77
• MDL number: MFCD00060740
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Propiedades

• description: Merck USA index - 14, 7147
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• optical activity: [α]20.0/D -90.0±5.0, c = 0.5 in methanol
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 1 mg/mL, methanol: 1 mg/mL
• storage temp.: 2-8°C
• SMILES string: N([C@@H](C(C)C)C(=O)NC(C(O)CC(=O)N[C@@H](C)C(=O)NC(C(O)CC(=O)O)CC(C)C)CC(C)C)C(=O)[C@@H](NC(=O)CC(C)C)C(C)C
• InChI: 1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23?,24?,25?,26?,30-,31-/m0/s1
• InChI key: FAXGPCHRFPCXOO-JHTFMCFMSA-N

Descripción

General description

A reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 508437).

Effective concentration: 1.0 µM.

Biochem/physiol Actions

EC50 = 1.0 µM in blocking apoptosis induced by CA-074 in PC12 cell lines

Primary Target
cathepsin D

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Isahara, K., et al. 1999. Neuroscience91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun.251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res.40, 233.
Carraway, R.E., et al. 1991. Peptides12, 107.
Eid, M., et al. 1981. Biochem. J.197, 465.
Umezawa, H., et al. 1970. J. Antibiot.23, 259.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable