343290

Fluoxetine hydrochloride

≥98% (HPLC), solid, selective serotonin re-uptake inhibitor, Calbiochem

• Sinónimos: Fluoxetine, Hydrochloride, dl-N-Methyl-3-( p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro- p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac
• Fórmula empírica (notación de Hill): C₁₇H₁₈F₃NO
• Número CAS: 56296-78-7
• Peso molecular: 309.33
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00214288
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Propiedades

• Nombre del producto: Fluoxetine, Hydrochloride, A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI).
• Quality Segment: 100
• description: Merck USA index - 14, 4185
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• solubility: methanol: 100 mg/mL, water: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: FC(F)(F)c1ccc(cc1)OC(CCNC)c2ccccc2.[Cl-].[H+]
• InChI: 1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H
• InChI key: GIYXAJPCNFJEHY-UHFFFAOYSA-N

Descripción

General description

A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T cells by increasing the Ca²⁺ influx thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Inhibits leak K⁺ currents in a reversible and voltage-independent manner (IC₅₀ = 780 nM). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of Mr 32,000) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Triggers oxidative stress-induced apoptotic cell death and initiates signaling pathways in neuronal cells leading to an activation of ERK and NF-κB.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Selective serotonin re-uptake inhibitor

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bartholoma, P., et al. 2002. Biochem. Pharmacol.63, 1507.
Bian, J.T., et al. 2002. Eur. J. Pharmacol.453, 159.
Zhang, A., et al. 2002. J. Med. Chem.45, 1930.
Svenningsson, P., et al. 2002. Proc. Natl. Acad. Sci. USA99, 3182.
Edgar, V.A., et al. 1999. Eur. J. Pharmacol.372, 65.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Información de seguridad

• Pictogramas: GHS08,GHS05,GHS07,GHS09
• Palabra de advertencia: Danger
• Códigos de peligro: H302,H318,H336,H373,H410
• Indicaciones de precaución: P260 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3
• Órganos diana: Central nervous system
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable