219478

Cdk4 Inhibitor III

The Cdk4 Inhibitor III, also referenced under CAS 265312-55-8, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: Cdk4 Inhibitor III, 5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine
• Fórmula empírica (notación de Hill): C₁₅H₁₂N₂O₂S
• Número CAS: 265312-55-8
• Peso molecular: 284.33
• MDL number: MFCD09971103
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥90% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Propiedades

• Quality Segment: 100
• assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: black-purple
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [s]1c2c(nc1C)C(=O)C(=CC2=O)Nc3ccc(cc3)C
• InChI: 1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3
• InChI key: HFPLHASLIOXVGS-UHFFFAOYSA-N

Descripción

General description

A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC₅₀ = 6.0 µM for Cdk4/D1 and >200 µM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC₅₀ = 0.61, 1.08, 0.30, and 1.21 µg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).

Biochem/physiol Actions

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 6.0 µM for Cdk4/D1 and >200 µM for Cdk2/A

Cell permeable: yes

Primary Target
Cdk4

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ryu, C.K., et al. 2000. Bioorg. Med. Chem. Lett.10, 461.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable