1065210

Berberine chloride

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): Berberine chloride form, Natural Yellow 18
• Empirical Formula (Hill Notation): C₂₀H₁₈ClNO₄
• CAS Number: 633-65-8
• Molecular Weight: 371.81
• PubChem Substance ID: 329748923
• UNSPSC Code: 41116107
• NACRES: NA.24
• MDL number: MFCD00011939
• Colour Index Number: 75160
• Beilstein/REAXYS Number: 3836585

Properties

• grade: pharmaceutical primary standard
• agency: USP
• API family: berberine
• manufacturer/tradename: USP
• application(s): pharmaceutical; pharmaceutical; pharmaceutical (small molecule)
• format: neat
• SMILES string: COC1=C(C=[N+](CCC2=C3C=C4C(OCO4)=C2)C3=C5)C5=CC=C1OC.[Cl-]
• InChI: 1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
• InChI key: VKJGBAJNNALVAV-UHFFFAOYSA-M

Description

General description

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This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Berberine chloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Coptis Species Rhizome
• Coptis Species Rhizome Dry Extract
• Coptis Species Rhizome Powder
• Goldenseal
• Indian Barberry Stem
• Indian Barberry Stem Dry Extract
• Indian Barberry Stem Powder

Fluorescent stain for heparin in mast cells

Biochem/physiol Actions

An alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5´-methoxyhydnocarpin (5´-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• Storage Class: 11 - Combustible Solids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable