V9505

Monoclonal Anti-Vitamin B₁₂ antibody produced in mouse

clone CD-29, ascites fluid

• Synonym(s): Anti-Cyanocobalamin
• UNSPSC Code: 12352203
• NACRES: NA.46
• MDL number: MFCD00164758
• Conjugate: unconjugated
• Clone: CD-29, monoclonal
• Application: ELISA (i)
• Citations: 10

Properties

• biological source: mouse
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: ascites fluid
• antibody product type: primary antibodies
• clone: CD-29, monoclonal
• contains: 15 mM sodium azide
• technique(s): indirect ELISA: 1:5,000
• isotype: IgG1
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified

Description

General description

Monoclonal Anti-Vitamin B₁₂ antibody reacts with vitamin B₁₂, as well as with vitamin B₁₂-KLH and vitamin B₁₂-BSA conjugates in human plasma and serum.

Vitamin B12 or cobalamin is a water-soluble vitamin. It is the largest and most complex among all the vitamins. Vitamin B12 is naturally found in animal foods, meat, milk, egg, fish and shellfish.

Application

Monoclonal Anti-Vitamin (B₁₂) antibody has been used in enzyme linked immunosorbent assay (ELISA)

Monoclonal Anti-Vitamin B12 antibody produced in mouse has also been used in immunocytochemistry.

Biochem/physiol Actions

Vitamin B12 serves as a cofactor for methionine synthase and L-methylmalonyl−coenzyme A mutase. It is essential for the maintenance and development of CNS. Vitamin B12 deficiency leads to megaloblastic anemia and neuropathy.

Vitamin B₁₂ regulates genomic stability. While increased levels of vitamin B₁₂ have been associated with hepatic and hematological disorders; cobalamin deficiency has been associated with orthostatic hypotension and depression . The antibody also detects coenzyme B₁₂ and methyl vitamin B₁₂, but does not associate with BSA, folic acid, and 5-methyltetrahyrofolic acid.

Vitamin B₁₂ and folic acid can be used for treating disorders of central nervous system (CNS) development, mood, and cognitive decline, including some dementias.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable