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SML2235

CL075

≥98% (HPLC)

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Synonym(s):

2-Propylthiazolo[4,5-c]quinolin-4-amine, 3M002

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Size/SKUAvailabilityPrice
5 mg
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CLP 118,000
CLP 100,300
25 mg
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CLP 499,000

About This Item

Empirical Formula (Hill Notation):
C13H13N3S
CAS Number:
Molecular Weight:
243.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

CLP 100,300

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[s]1c2c(nc1CCC)c(nc3c2cccc3)N

InChI

1S/C13H13N3S/c1-2-5-10-16-11-12(17-10)8-6-3-4-7-9(8)15-13(11)14/h3-4,6-7H,2,5H2,1H3,(H2,14,15)

InChI key

NFYMGJSUKCDVJR-UHFFFAOYSA-N

Application

CL075 has been used to activate the monocyte-derived dendritic cells (DCs) to demonstrate the ability of DCs to induce cell death.

Biochem/physiol Actions

CL075 is a selective agonist of Toll-like receptor-8 (TLR-8) with immunostimulant activity. It showed an EC50 value of 400nM for IRF-NFΚB stimulation in TLR8 compared to 4 μM for TLR7.
Toll-like receptor-8 (TLR-8) agonist
CL075 is a thiazoloquinolone derivative. It might influence tumor development.

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This Item
SML2566SML0376SML2495
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: >2 mg/mL (warmed)

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to very dark brown

color

light yellow to light brown

color

white to gray-brown


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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